Table 2 of
Wang, Mol Vis 2007;
13:1357-1362.Table 2 of
Wang, Mol Vis 2007;
13:1357-1362.
Table 2. Genes and loci with unidentified genes responsible for isolated inherited nuclear cataract
Eight genes and six loci have been reported to be involved in autosomal dominant and autosomal recessive inherited nuclear cataracts in many families with different origin. AD indicates autosomal dominant inherited catatact, AR indicates autosomal recessive inherited cataract.
Locus Gene Inheritance Phenotype Origin Reference
------------- --------- ----------- --------------------------- --------- ---------
1pter-p36.13 AD Volkmann type Danish [21]
1q21.1 GJA8 AD Zonular pulverulent English [16]
AD Zonular nuclear pulverulent Pakistani [17]
AD Zonular pulverulent Russian [18]
AD Nuclear Iranian [19]
AD Nuclear Chinese [20]
2p12 AD Nuclear Pakistani [26]
2q33-q35 CRYGC AD Zonular pulverulent Unknown [27]
CRYGD AD Nuclear Chinese [28]
13q11-q13 GJA3 AD Zonular pulverulent English [29]
AD Zonular pulverulent Caucasian [30]
AD Nuclear pulverulent Chinese [31,32]
AD Nuclear punctuate Caucasian [33]
AD Nuclear Chinese [20]
15q21-q22 AD Central pouch-like Indian [34]
17q11.1-q12 CRYBA1/A3 AD Nuclear Chinese [35]
19q13 AR Nuclear Pakistani [12]
21q22.3 CRYAA AD Nuclear Caucasian [36]
22q11.2-q12.2 CRYBB2 AD Coppock-like Swiss [37]
AD Central nuclear Indian [38]
CRYBB3 AR Nuclear Pakistani [4]
Xp22 X-linked Nuclear European [39]
|