Table 1 of
Weger, Mol Vis 2007;
13:1274-1279.
Table 1. Genotype distribution of the HTRA serine peptidase 1
A stepwise binary logistic regression analysis was performed to assess the influence of HTRA1 and complement factor H (CFH) genotypes on age-related macular degeneration (AMD) risk. To test for independence, interaction terms of HTRA1 and CFH genotypes were entered in the regression analysis and interaction terms between CFH and HTRA1 genotypes were not significantly associated with AMD, when adjusted for CFH and HTRA1 genotypes.
AMD Control Odds ratio Genotype patients subjects (95% confidence interval) p -------------- ----------- ---------- ------------------------- ------ HTRA1 -625 GG 67 (27.7%) 99 (63.1%) 1 (reference) - GA 108 (44.6%) 50 (31.8%) 2.7 (1.1-6.8) 0.034 AA 67 (27.7%) 8 (5.1%) 10.2 (3.0-34.5) <0.001 CFH 402 YY 38 (15.7%) 78 (49.7%) 1 (reference) - YH 121 (50.0%) 65 (41.4%) 3.6 (1.6-7.9) 0.001 HH 83 (34.3%) 14 (8.9%) 9.8 (3.7-25.9) <0.001 |