Table 1 of Weger, Mol Vis 2007; 13:1274-1279.


Table 1. Genotype distribution of the HTRA serine peptidase 1

A stepwise binary logistic regression analysis was performed to assess the influence of HTRA1 and complement factor H (CFH) genotypes on age-related macular degeneration (AMD) risk. To test for independence, interaction terms of HTRA1 and CFH genotypes were entered in the regression analysis and interaction terms between CFH and HTRA1 genotypes were not significantly associated with AMD, when adjusted for CFH and HTRA1 genotypes.


                    AMD         Control          Odds ratio
   Genotype       patients      subjects    (95% confidence interval)     p
--------------   -----------   ----------   -------------------------   ------
HTRA1 -625  GG    67 (27.7%)   99 (63.1%)      1 (reference)             -
            GA   108 (44.6%)   50 (31.8%)      2.7 (1.1-6.8)            0.034
            AA    67 (27.7%)    8 (5.1%)       10.2 (3.0-34.5)          <0.001
CFH 402 YY        38 (15.7%)   78 (49.7%)      1 (reference)             -
        YH       121 (50.0%)   65 (41.4%)      3.6 (1.6-7.9)            0.001
        HH        83 (34.3%)   14 (8.9%)       9.8 (3.7-25.9)           <0.001

Weger, Mol Vis 2007; 13:1274-1279 <http://www.molvis.org/molvis/v13/a138/>
©2007 Molecular Vision <http://www.molvis.org/molvis/>
ISSN 1090-0535