Figure 6. Minocycline delayed the photoreceptor apoptosis in rds mice

A: The retinal sections from the minocycline-treated rds eyes harbored a thicker outer nuclear layer (ONL). The difference was statistically significant at P21. B: The retinal sections from the minocycline-treated rds eyes displayed roughly 30% fewer TUNEL labeling at P17 than un-treated eyes. The difference was statistically significant, however the difference was statistically insignificant at P21. At P28, the number of TUNEL-positive cells in the minocycline-treated retina was more than those in the un-treated retina. The difference was statistically insignificant. C: Minocycline treatment had no significant effect on the number of ONL microglia in rds retina. Data were expressed as mean±SD. A p<0.01 (*) was considered significant compared with the age-paired un-treated retina.