Figure 1. Pedigrees of novel reported Spanish families with mutation in the peripherin/RDS gene

Solid, open, and scored symbols indicate affected, unaffected and deceased individuals, respectively; arrows indicate probands. Bottom numbered symbols in pedigree correspond to individuals whose DNA has been analyzed by DGGE and sequencing- In chromatogram of direct genomic sequencing of mutation, arrows indicate position of mutation. AVMD indicates adult viteliform macular dystrophy; BPD indicates butterfly-shaped pattern dystrophy; CACD indicates central areolar choroidal dystrophy; PMD indicates pattern macular dystrophy.