Table 3 of
Kamphuis, Mol Vis 2007;
13:1020-1030.Table 3 of
Kamphuis, Mol Vis 2007;
13:1020-1030.
Table 3. Results of gene ontology-term based clustering
Fold change for the different ischemic preconditioning intervals are in red color when fold change is least 1.7-times and the methodological error is p<0.01, in black when the methodological error is p<0.01. PCR column indicates whether the qPCR assay confirms the array outcome (=). UniGene names indicated by asterisk are added to the cluster on basis of other functional annotation than GOStat or DAVID. Lars and Iars were represented by two different probes (prb) on the array.
UniGene
name 1 h 3 h 6 h 12 h 24 h 48 h 7 d PCR Abbreviated description
----------- ---- ---- ---- ---- ---- ---- ---- --- --------------------------------------
Aminoacyl-tRNA synthetase, [David Enrichment score 3.59], translation
Tars -1.1 1.3 -1.3 1.1 -1.7 -1.5 1.0 = Rat threonyl-tRNA synthetase
Cars -1.2 1.2 -1.2 -1.1 -1.8 -1.4 1.0 Cysteinyl-tRNA synthetase
Lars (prb1) -1.2 -1.0 -1.1 1.1 -1.7 -1.7 -1.1 = Leucyl-tRNA synthetase
Lars (prb2) -1.3 1.0 -1.1 1.1 -1.7 -1.6 -1.0 = Leucyl-tRNA synthetase
Yars -1.0 1.1 -1.1 -1.1 -1.7 -1.5 -1.0 = Tyrosyl-tRNA synthetase
Gars -1.2 -1.0 -1.1 1.0 -1.7 -1.4 1.0 Glycyl-tRNA synthetase
Iars (prb1) -1.1 1.1 -1.2 1.0 -1.8 -1.6 -1.0 = Isoleucine-tRNA synthetase
Iars (prb2) -1.3 1.3 -1.2 -1.1 -1.8 -1.5 1.1 = Isoleucine-tRNA synthetase
Bzw2 -1.1 -1.0 -2.3 1.1 -1.1 -1.3 1.2 Basic leucine zipper and W2 domains 2
Gtpbp2 -1.2 1.0 -1.1 -1.1 1.0 -2.4 1.0 GTP binding protein 2
Eif2s2 -1.3 1.2 -1.2 1.1 -1.4 -1.7 1.0 = Rat eukaryotic translation initiation
factor 2, subunit 2 beta
Mthfd* 1.2 1.0 -2.4 -1.0 -2.3 -2.8 -1.2 Similar to methylenetetrahydrofolate
dehydrogenase (NAD)
Pop5* 1.4 1.0 -2.9 -1.1 1.3 1.6 1.8 Processing of precursor 5,
ribonuclease P/MRP family
Asns* -1.0 1.1 -1.1 -1.0 -1.7 -1.5 -1.0 = Asparagine synthetase
Amino acid transport [David Enrichment score 1.82]
Slc3a2 -1.1 1.2 -1.4 -1.1 -1.8 -1.4 -1.1 = Activators of dibasic and neutral
amino acid transpor, member 2
Slc6a6 1.7 -1.0 1.3 -1.4 1.5 1.3 1.2 = Neurotransmitter transporter, taurine,
member 6
Slc7a1 -1.1 1.4 -1.6 -1.1 -2.7 -2.2 -1.1 = Cationic amino acid transporter, y+
system, member 1
Slc38a2 -1.2 1.0 -1.5 1.0 -1.5 -1.7 -1.1 = Solute carrier family 38, member 2
Cell death [David Enrichment score 1.88]
Emp1 -1.5 -1.2 3.5 1.9 -1.1 -1.5 -1.3 Epithelial membrane protein 1
Anxa1 -1.7 -2.3 3.8 2.1 1.1 -1.2 -1.1 = Annexin A1
Trib3 -1.1 -1.2 -2.9 -1.2 -1.3 -1.9 -1.0 = Tribbles homolog 3 (Drosophila)
Lcn2 1.2 1.2 -1.6 2.3 2.5 -2.0 -1.6 Lipocalin 2
Perp1 -1.3 -1.7 2.3 1.2 -1.2 -1.1 -1.2 PERP, TP53 apoptosis effector
Lgals7 -1.1 -2.7 2.9 -1.2 1.0 -1.0 -1.3 Lectin, galactose binding, soluble 7
Ccl6 -1.5 -1.6 2.2 1.2 -1.0 -1.1 -1.2 Chemokine (C-C motif) ligand 6
Klf10 2.0 -1.1 1.1 1.1 1.0 -1.1 -1.0 Kruppel-like factor 10
Regulation of transcription, DNA-dependent [David Enrichment score 1.55]
Atf3 -1.1 -1.3 -3.1 1.1 -2.0 -3.3 -1.2 = Activating transcription factor 3
Nr4a1 4.0 -1.4 -1.3 -1.2 1.0 -1.3 1.0 = Nuclear receptor subfamily 4, group A,
member 1
Nr4a3 5.4 -2.4 -2.1 1.0 -1.2 -1.9 -1.8 = Nuclear receptor subfamily 4, group A,
member 3
Cebpd 1.5 1.2 1.2 2.0 1.5 -1.9 -1.0 = CCAAT/enhancer binding protein
(C/EBP), delta
Egr1 5.0 1.2 3.1 -1.1 -1.5 -2.1 -1.1 = Early growth response 1
Egr4 2.9 -1.4 -1.1 -1.2 -1.1 1.1 -1.2 Early growth response 4
Jund 1.7 -1.0 -1.1 -1.1 1.1 -1.0 -1.0 Jun D proto-oncogene
Fgfbp1 -1.2 -1.3 1.5 1.1 -1.1 -2.0 -1.0 Fibroblast growth factor binding
protein 1
Snf1lk 1.2 -2.0 -1.4 -1.1 -1.0 -1.2 -1.2 SNF1-like kinase
Zfp36 1.8 1.1 1.1 1.1 -1.2 -1.2 1.1 Zinc finger protein 36
Arid1a 1.2 1.4 1.2 1.4 1.4 2.7 1.5 AT rich interactive domain 1A (Swi1
like)
Klf4 2.1 -1.0 -1.3 1.2 -1.1 -1.3 -1.2 Kruppel-like factor 4 (gut)
Atf7ip -1.1 -1.1 -2.7 1.1 -1.6 -1.8 -1.9 Activating transcription factor 7
interacting protein
c-fos 2.6 -1.4 1.0 1.1 -1.1 -1.3 1.0 = FBJ murine osteosarcoma viral oncogene
homolog (Fos)
Cdc73 -1.2 -2.3 -1.0 1.2 1.2 1.1 -1.1 Cell division cycle 73, Paf1/RNA
polymerase II complex component
Fosl2* 1.2 -1.7 -1.2 1.0 -1.1 -1.7 -1.3 Fos-like antigen 2
Hes5* -1.7 1.0 1.2 -1.1 -1.0 1.0 1.1 Hairy and enhancer of split 5
(Drosophila)
Arid2* 1.2 -1.2 1.1 1.0 1.1 -2.3 -1.3 AT rich interactive domain 2 (Arid-rfx
like)
Arid5a* 1.8 -1.2 -1.2 -1.0 -1.1 -1.1 -1.1 AT rich interactive domain 5A (Mrf1
like)
Nab2* 2.3 1.8 1.3 -1.0 1.2 1.0 1.1 = Ngfi-A binding protein 2
Lix1* 1.3 2.1 1.0 -1.2 1.0 1.3 1.1 Similar to Lix1 homolog (mouse) like
(LOC499677)
Phf20* 1.3 1.7 -1.0 -1.2 1.2 1.0 -1.1 Similar to PHD finger protein 20
Anchored to cell membrane
Cp -1.2 1.0 1.2 2.0 1.2 -1.2 1.2 Ceruloplasmin
Tmprss8 -2.2 -1.8 1.2 1.2 1.2 1.1 1.3 Transmembrane protease, serine 8
(intestinal)
Intermediate filament, cytoskeletal part
Lmna* 1.7 1.3 -1.1 -1.0 1.0 -1.0 -1.0 Lamin A
Gfap* 1.2 1.6 1.4 2.0 1.8 -1.4 1.3 Glial fibrillary acidic protein
Emd* 1.7 1.2 1.1 -1.2 -1.1 -1.0 -1.0 Emerin
Tubb6* 1.6 1.7 1.8 1.2 1.2 -1.5 -1.0 Tubulin, beta 6
Pdlim3* 1.8 1.7 1.2 1.2 1.1 1.0 1.2 PDZ and LIM domain 3
Dsc2* -1.3 1.4 2.9 1.4 -1.0 -1.2 -1.1 Desmocollin 2
Mpp2* 1.1 -1.1 1.2 2.9 1.1 1.5 1.4 Membrane protein, palmitoylated 2
Enc1* 1.8 1.2 1.9 -1.5 1.7 2.2 3.6 Ectodermal-neural cortex 1
Nexn* -1.2 -1.0 -1.0 1.0 -1.7 -1.1 1.1 Nexilin
Mfap3* -1.1 2.4 1.1 -1.1 1.4 -1.0 1.4 Microfibrillar-associated protein 3
Sdc1* -1.1 -1.8 2.4 1.1 -1.6 -2.0 -2.4 Syndecan 1
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