Table 3 of
Mutti, Mol Vis 2007;
13:1012-1019.Table 3 of
Mutti, Mol Vis 2007;
13:1012-1019.
Table 3. Model-free tests of association with myopia
The significant finding from the analysis is an association between myopia and COL2A1 (rs1635529). The p value for FGF2 (rs1048201) is not significant after correction for multiple comparisons. The significant p value is marked in red. In the table, NR indicates the p-value was not reported due to an insufficient number of informative families. Also, NS indicates the p-value is not significant for any allele with a sufficient number of informative families.
TDT analysis
------------------------------------
Number of p-values
informative ----------------------
Marker Location families Bi-allelic Haplotype
-------------------- -------- ----------- ---------- ---------
Chromosome 4
FGF2 rs1048201 4q27 32 0.01
FGF2 rs1982569 4q27 42 0.13 0.59
FGF2 rs308447 4q27 25 0.83
Chromosome 11
PAX6 rs3026401 11p13 22 0.62
PAX6 rs662702 11p13 8 NR
PAX6 rs1506 11p13 4 NR
PAX6 rs2239789 11p13 56 0.89 0.79
PAX6 rs628224 11p13 24 0.22
BDNF rs6265 11p14.1 29 0.67
Chromosome 12
COL2A1 rs1635529 12q13.11 44 0.00007
COL2A1 rs1635550 12q13.11 34 0.19 0.78
COL2A1 rs2248990 12q13.11 65 0.54
COL2A1 rs3737548 12q13.11 58 0.13
D12S2076 (GATA30F04) 12q21.31 37 NS
D12S1051 (GATA2401) 12q23.1 32 NS
D12S2081 (GATA7A02) 12q23.1 42-46 NS
D12S393 (GATA15A03) 12q23.1 10-60 NS
D12S1059 (GATA47G01) 12q23.1 17 NS
D12S1041 (ATA24F01) 12q23.1 10-59 NS
D12S1030 (GATA6H09) 12q23.2 32-54 NS
Chromosome 18
D18S476 18p11.32 12-31 NS
GATA178F11 18p11.32 10-16 NS
D18S52 18p11.32 11-37 NS
GATA185C06 18p11.32 14-38 NS
D18S967 (GATA116D12) 18p11.32 20-61 NS
Chromosome 21
COL18A1 rs9983675 21q22.3 58 0.84
COL18A1 rs1051298 21q22.3 63 0.85 0.77
COL18A1 rs2236479 21q22.3 30 0.24
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