Table 2 of
Seitsonen, Mol Vis 2006;
12:796-801.Table 2 of
Seitsonen, Mol Vis 2006;
12:796-801.
Table 2. Allele and genotype frequencies and results of association tests of Tyr402His polymorphism in the complement factor H gene
The genotype and allele frequencies are shown for cases and controls (A). Familial and sporadic age-related macular degeneration (AMD) cases are compared to non-AMD controls (B) and blood donor controls (C) for the Tyr402His polymorphism in the complement factor H (CFH) gene. The p values, odds ratios and confidence intervals (CI) are for the comparision of familial, sporadic, and all (combined analysis of familial and sporadic) AMD cases to non-AMD and blood donor controls within each group. No significant difference exists in the allele or the genotype frequencies of Tyr402His polymorphism between familial and sporadic cases.
A:
Blood
Familial Sporadic All AMD Non-AMD donor
cases cases cases controls controls
(n=181) (n=154) (n=335) (n=105) (n=350)
-------- -------- -------- ------- -------- --------
Genotype
C/C 0.453 0.383 0.421 0.124 0.200
T/C 0.420 0.500 0.457 0.524 0.491
T/T 0.127 0.117 0.122 0.352 0.309
Allele
C 0.663 0.633 0.649 0.386 0.446
T 0.337 0.367 0.351 0.614 0.554
|
B:
Comparison Familial cases Sporadic cases All AMD cases -------------- ---------------- ---------------- ---------------- C/C versus T/C OR (95% CI) 4.56 (2.31-9.01) 3.24 (1.62-6.48) 3.90 (2.04-7.44) p value 0.00000467 0.000629 0.0000146 C/C versus T/T OR (95% CI) 10.1 (4.64-22.2) 9.33 (4.10-21.3) 9.79 (4.76-20.1) p value 0.000000000483 0.0000000185 0.00000000000886 T/C versus T/T OR (95% CI) 2.22 (1.19-4.16) 2.88 (1.49-5.57) 2.51 (1.46-4.31) p value 0.0115 0.00142 0.000712 C versus T OR (95% CI) 3.13 (2.20-4.46) 2.75 (1.91-3.94) 2.95 (2.14-4.06) p value 0.000000000118 0.0000000301 0.0000000000132 |
C:
Comparison Familial cases Sporadic cases All AMD cases -------------- ---------------- ---------------- ---------------- C/C versus T/C OR (95% CI) 2.65 (1.75-4.03) 1.88 (1.21-2.92) 2.26 (1.58-3.25) p value 0.00000370 0.00444 0.00000717 C/C versus T/T OR (95% CI) 5.50 (3.17-9.55) 5.06 (2.75-9.28) 5.31 (3.35-8.40) p value 0.000000000264 0.0000000452 0.0000000000002 T/C versus T/T OR (95% CI) 2.07 (1.23-3.51) 2.69 (1.52-4.73) 2.34 (1.54-3.57) p value 0.00581 0.000468 0.0000580 C versus T OR (95% CI) 2.45 (1.89-3.19) 2.15 (1.63-2.83) 2.30 (1.85-2.86) p value 0.0000000000185 0.0000000421 <0.0000000000001 |