Table 7 of
Liton, Mol Vis 2006;
12:774-790.
Table 7.
List of the known genes significantly downregulated in POAG trabecular meshwork (TM) tissue. Genes were present in all the control samples. The presence of (P), marginal (M), or absence of (A) a signal in each of the two POAG samples is indicated in the POAG TM column.
Fold POAG Gene name Unigene change p value TM ----------------------------------------- --------- ------ -------- ---- VPS10 domain receptor protein SORCS 3 SORCS3 9.021 0.0026 A mitogen-activated protein kinase 6 MAP2K6 5.794 0.0108 P cadherin 10, type 2 (T2-cadherin) CDH10 5.041 0.00537 P,A TPTE and PTEN homologous inositol lipid TPTEps1 4.992 0.000971 A phosphatase pseudogene calbindin 1, 28 kDa CALB1 4.907 0.00917 P,M leucine-rich, glioma inactivated 1 LGI1 3.976 0.00129 P matrix metalloproteinase 10 MMP10 3.97 0.0094 P (stromelysin 2) testis expressed sequence 15 TEX15 3.821 0.0317 A WNT inhibitory factor 1 WIF1 3.774 0.0151 P carboxylesterase 1 (monocyte/macrophage CES1 3.352 0.0417 P,A serine esterase 1) growth arrest-specific 7 GAS7 3.186 0.0365 P,A protein kinase, lysine deficient 4 PRKWNK4 3.117 0.0145 P cytochrome P450, family 39, subfamily A, CYP39A1 3.1 0.000473 P polypeptide 1 glycoprotein hormone alpha 2 GPHA2 3.012 0.000588 P ATP-binding cassette, sub-family A ABCA9 2.822 0.00679 A (ABC1), member 9 purinergic receptor P2Y, G-protein P2RY12 2.684 0.0048 P,A coupled, 12 nebulin NEB 2.627 0.00939 P cortactin binding protein 2 CORTBP2 2.575 0.0111 P proprotein convertase subtilisin/kexin PCSK1N 2.575 0.0259 P type 1 inhibitor paraoxonase 3 PON3 2.523 0.006 A solute carrier family 10, member 4 SLC10A4 2.496 0.000439 P cancer susceptibility candidate 1 CASC1 2.436 0.0188 P solute carrier family 35, member D1 SLC35D1 2.296 0.00196 P ceruloplasmin CP 2.282 0.00137 P tripartite motif protein TRIM9 isoform TRIM9 2.235 0.0246 P alpha (TRIM9) protocadherin beta 6 PCDHB6 2.223 1.49E-05 P cadherin-like 24 CDH24 2.221 0.00234 A low density lipoprotein-related protein LRP1B 2.221 0.0183 P 1B (deleted in tumors) solute carrier family 6 (neurotransmitter SLC6A1 2.218 0.00295 P transporter, GABA), member 1 frizzled homolog 10 (Drosophila) FZD10 2.18 0.00155 P H19, imprinted maternally expressed H19 2.179 0.00277 P untranslated mRNA adrenergic, beta-2-, receptor, surface ADRB2 2.157 0.00589 P serine protease EOS EOS 2.146 0.00748 P,A X transporter protein 3 SLC6A20 2.115 0.00243 P delta-notch-like EGF repeat-containing DNER 2.11 0.011 P,M transmembrane protein phosphatase 1, regulatory PPP1R1B 2.089 0.0198 P (inhibitor) subunit 1B B-cell CLL/lymphoma 6, member B (zinc BCL6B 2.078 0.0495 P,M finger protein) iduronidase, alpha-L- IDUA 2.052 0.00162 A GATA binding protein 6 GATA6 2.04 0.0433 P EGF-like-domain, multiple 6 EGFL6 2.035 0.00526 P SMA3 LOC153561 2.023 0.0141 P EH-domain containing 3 EHD3 2.015 0.0307 P,A sortilin-related receptor, L(DLR class) A SORL1 2.009 0.000666 P repeats-containing acyl-Coenzyme A dehydrogenase, long chain ACADL 2.005 0.000153 A |