Table 5 of
Inagaki, Mol Vis 2006;
12:673-680.Table 5 of
Inagaki, Mol Vis 2006;
12:673-680.
Table 5.
Clinical characteristics of glaucoma patients according to genotype for Gln27Glu in the ADRB2 gene. Differences in the dominant model of polymorphisms of ADRB2/Gln27Glu in association with three clinical characteristics are shown. Associations between clinical characteristics and genotypes were assessed by multivariate analyses carried out with a logistic regression model. For the Gln27Glu polymorphism in the ADRB2 gene, IOPs at diagnosis were significantly higher in OAG patients with Gln/Glu+Glu/Glu (24.2±9.2 mmHg) than in those with Gln/Gln (20.2±5.9 mmHg, p<0.001). P values were calculated with logistic regression analysis. The asterisk indicates a p<0.05.
Genotype
------------------------------------
Phenotype Clinical characteristics Gln/Gln Gln/Glu+Glu/Glu p value*
--------- ------------------------------- ----------------- ---------------- --------
OAG Age at diagnosis (years) 56.7±12.7 (n=412) 57.1±12.3 (n=53) 0.448
IOP at diagnosis (mm Hg) 20.2± 5.9 (n=374) 24.2± 9.2 (n=45) <0.001*
Visual field score at diagnosis 2.9± 0.8 (n=414) 2.9± 0.8 (n=54) 1.000
POAG Age at diagnosis (years) 58.4±12.3 (n=162) 56.3± 2.2 (n=30) 0.272
IOP at diagnosis (mm Hg) 26.0± 5.1 (n=144) 28.6± 9.1 (n=28) 0.038*
Visual field score at diagnosis 3.1± 0.9 (n=163) 3.1± 0.9 (n=30) 0.837
NTG Age at diagnosis (years) 55.6±12.8 (n=250) 58.2±12.6 (n=23) 0.986
IOP at diagnosis (mm Hg) 16.6± 2.5 (n=230) 17.1± 2.0 (n=17) 0.447
Visual field score at diagnosis 2.8± 0.7 (n=251) 2.8± 0.6 (n=24) 0.692
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