Table 3 of
Inagaki, Mol Vis 2006;
12:673-680.Table 3 of
Inagaki, Mol Vis 2006;
12:673-680.
Table 3.
Allele and genotype frequency of ADRB1 and ADRB2 polymorphisms in Japanese glaucoma patients and controls. Data shown are counts with percentage in parentheses. Frequencies of genotypes and alleles were compared between patients and controls by χ2 analysis. The Bonferroni correction was used to adjust for multiple comparisons for static analysis of each SNP. The Arg389Gly polymorphism of the ADRB1 gene was significantly associated with NTG, showing a significantly different allele frequency in NTG patients and control subjects (p=0.004). Distribution of the Arg389Gly genotype also differed significantly between NTG patients and control subjects (p=0.006). P value from χ2 test. The asterisk indicates a p<0.0125, Bonferroni correction.
Allele frecuency (percentage) Genotype frequency (percentage)
--------------------------------------------- ---------------------------------------------
Polymorphism Allele OAG POAG NTG Control Genotype OAG POAG NTG Control
------------ ------ --------- --------- --------- --------- -------- --------- --------- --------- ---------
(n=1010) (n=422) (n=588) (n=480) (n=505) (n=211) (n=294) (n=240)
ADRB1 Ser 872(86.3) 362(85.8) 510(86.7) 415(86.5) Ser/Ser 374(74.1) 155(73.5) 219(74.5) 176(73.3)
Ser49Gly Gly 138(13.7) 60(14.2) 78(13.3) 65(13.5) Ser/Gly 124(24.6) 52(24.6) 72(24.5) 63(26.3)
Gly/Gly 7( 1.4) 4( 1.9) 3( 1.0) 1( 0.4)
p=0.949 p=0.769 p=0.895 p=0.405 p=0.313 p=0.666
(n=1002) (n=420) (n=582) (n=474) (n=501) (n=210) (n=291) (n=237)
ADRB1 Arg 821(81.9) 332(79.0) 489(84.0) 365(77.0) Arg/Arg 335(66.9) 132(62.9) 203(69.8) 143(60.3)
Arg389Gly Gly 181(18.1) 88(21.0) 93(16.0) 109(23.0) Arg/Gly 151(30.1) 68(32.4) 83(28.5) 79(33.3)
Gly/Gly 15( 3.0) 10(4.8) 5( 1.7) 15( 6.3)
p=0.026 p=0.462 p=0.004* p=0.050 p=0.728 p=0.006*
(n=950) (n=406) (n=544) (n=472) (n=475) (n=203) (n=272) (n=236)
ADRB2 Arg 470(49.5) 189(46.6) 281(51.7) 224(47.5) Arg/Arg 100(21.1) 39(19.2) 61(22.4) 53(22.5)
Arg16Gly Gly 480(50.5) 217(53.4) 263(48.3) 248(52.5) Arg/Gly 270(56.8) 111(54.7) 159(58.5) 118(50.0)
Gly/Gly 105(22.1) 53(26.1) 52(19.1) 65(27.5)
p=0.474 p=0.789 p=0.182 p=0.178 p=0.580 p=0.062
(n=938) (n=388) (n=550) (n=466) (n=469) (n=194) (n=275) (n=233)
ADRB2 Gln 881(93.9) 358(92.3) 523(95.1) 432(92.7) Gln/Gln 415(88.5) 164(84.5) 251(91.3) 199(85.4)
Gln27Glu Glu 57( 6.1) 30( 7.7) 27( 4.9) 34( 7.3) Gln/Glu 51(10.9) 30(15.5) 21( 7.6) 34(14.6)
Glu/Glu 3( 0.6) 0( 0.0) 3( 1.1) 0( 0.0)
p=0.382 p=0.810 p=0.111 p=0.179 p=0.969 p=0.031
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