Table 2 of
Yao, Mol Vis 2006;
12:649-654.Table 2 of
Yao, Mol Vis 2006;
12:649-654.
Table 2. Genotype and allele frequencies of the SNPs at IVS8 +4 and +32
The significance for comparing normal tension glaucoma (NTG) participants with controls and for comparing POAG/IOP participants with controls are shown under the headings p (NTG) and p (POAG), respectively. For three comparisons, significant p values are at 0.017. The asterisk indicates that Fisher's exact test was applied due to small sample size and the sharp (hash mark) indicates that the IVS8 +32 alleles show a marginally significant deviation from Hardy-Weinberg equilibrium in the POAG group only.
NTG POAG/IOP Controls p p
Location Allele Genotype n (%) n (%) n (%) (NTG) (POAG)
--------- ------ -------- ---------- --------- --------- ----- ------
IVS8 +4 C 119 (97.5) 95 (99.0) 94 (97.9)
T 3 (2.5) 1 (1.0) 2 (2.1) 0.11* 1.00*
CC 58 (95.1) 47 (97.9) 46 (95.8)
CT 3 (4.9) 1 (2.1) 2 (4.2) 0.11* 1.00*
IVS8 +32# T 58 (47.5) 56 (58.3) 58 (60.4)
C 64 (52.5) 40 (41.7) 38 (39.6) 0.06 0.77
TT 14 (22.9) 20 (41.7) 16 (33.3) 0.23 0.40
TC 30 (49.2) 16 (33.3) 26 (54.2) 0.61 0.04
CC 17 (27.9) 12 (25.0) 6 (12.5) 0.05 0.12
Combined comparison: p(NTG)=0.12, df=2; p(POAG)=0.09, df=2
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