Table 2 of Yao, Mol Vis 2006; 12:649-654.


Table 2. Genotype and allele frequencies of the SNPs at IVS8 +4 and +32

The significance for comparing normal tension glaucoma (NTG) participants with controls and for comparing POAG/IOP participants with controls are shown under the headings p (NTG) and p (POAG), respectively. For three comparisons, significant p values are at 0.017. The asterisk indicates that Fisher's exact test was applied due to small sample size and the sharp (hash mark) indicates that the IVS8 +32 alleles show a marginally significant deviation from Hardy-Weinberg equilibrium in the POAG group only.

                                   NTG       POAG/IOP    Controls      p       p
Location    Allele   Genotype     n (%)        n (%)       n (%)     (NTG)   (POAG)
---------   ------   --------   ----------   ---------   ---------   -----   ------
IVS8 +4       C                 119 (97.5)   95 (99.0)   94 (97.9)
              T                   3  (2.5)    1  (1.0)    2  (2.1)   0.11*   1.00*
                        CC       58 (95.1)   47 (97.9)   46 (95.8)
                        CT        3  (4.9)    1  (2.1)    2  (4.2)   0.11*   1.00*

IVS8 +32#     T                  58 (47.5)   56 (58.3)   58 (60.4)
              C                  64 (52.5)   40 (41.7)   38 (39.6)   0.06    0.77
                        TT       14 (22.9)   20 (41.7)   16 (33.3)   0.23    0.40
                        TC       30 (49.2)   16 (33.3)   26 (54.2)   0.61    0.04
                        CC       17 (27.9)   12 (25.0)    6 (12.5)   0.05    0.12
Combined comparison: p(NTG)=0.12, df=2; p(POAG)=0.09, df=2

Yao, Mol Vis 2006; 12:649-654 <http://www.molvis.org/molvis/v12/a73/>
©2006 Molecular Vision <http://www.molvis.org/molvis/>
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