Table 2 of John-Aryankalayil, Mol Vis 2006; 12:55-64.

Table 2. Microarray analysis of human pterygium and normal autologous conjunctiva

The table lists the Affymetric probe set name, the Genbank accession number, the fold change in gene expression in human pterygium relative to normal autologous conjunctiva by microarray analysis, and a brief description of the name or major function of the gene product. The genes shown are statistically significant with p<0.05.

  Affymetric   accession    Fold
     name       number     change            Name                              Description
  ----------   ---------   ------   ----------------------   -----------------------------------------------

Increased expression in pterygium

  311_s_at     X02761        8.5    Fibronectin              cell adhesion and migration
  34290_f_at   AA995126      5.0    TRAP100                  thyroid hormone receptor-associated protein
  32128_at     Y13710        4.9    MIP-4                    chemokine; pro-inflammatory
  32488_at     X14420        4.1    collagen III             cell adhesion and migration
  34778_at     AA418080      3.8    leucine rich repeat      integral to membrane
  38634_at     M11433        3.6    RBP1                     ligand trafficking; muscle malignancy
  38111_at     X15998        3.3    versican, V1             matrix expansion in arterial and smooth muscle
  37600_at     U68186        3.2    ECM 1                    extracellular matrix protein 1
  34015_at     AF004021      3.2    prostaglandin receptor   role in smooth muscle contraction
  32582_at     AF001548      3.1    myosin heavy chain 11    smooth muscle component
  40500_at     AF007138      3.1    NDRG4                    response to stress and cell differentiation
  34665_g_at   X62573        2.9    receptor for CD32        signal transduction, cell growth and
  38351_at     AL050154      2.8    mRNA; clone              from clone DKFZp586L0120
  37629_at     M55268        2.5    casein kinase 2          phosphorylation and signal transduction
  39710_at     U30521        2.5    C5orf13                  chromosome 5 open reading frame 13
  607_s_at     M10321        2.5    von Willebrand factor    platelet/cell adhesion, binds to collagen III
  32523_at     M20470        2.4    clathrin                 protein binding; membrane trafficking
  31610_at     U21049        2.4    MAP 17                   extracellular integral to membrane
  32821_at     A1762213      2.4    lipocalin 2              oncogene 24p3; transporter activity
  41362_at     X91249        2.3    ABCG1                    cholesterol and phospholipid transport
  34757_at     AA595596      2.3    ADPRTL2                  ribosyltransferase activity
  38327_at     M77348        2.2    SILV                     maturation of melanosomes
  41471_at     W72424        2.2    calgranulin B            inflammatory response; cell-cell signaling
  37269_at     D38496        2.2    LZTR1                    leucine-zipper-like transcriptional regulator 1
  479_at       U53446        2.1    DAB2                     cell proliferation, signal transduction
  38077_at     X52022        2.1    collagen type VI         cell adhesion and muscle development
  37398_at     AA100961      2.1    CD31 antigen (PECAM1)    endothelial cell adhesion, signal transduction
  33371_s_at   NM_006868     2.0    RAB31                    member of RAS oncogene family
  40161_at     L32137        2.0    COMP                     cartilage oligomeric matrix protein

Decreased expression in pterygium

  40013_at     BC022305     -2.0    CLIC2                    chloride intracellular channel 2
  36829_at     AF022991     -2.0    Per1                     circadian pacemaker protein
  40425_at     NM004428     -2.0    ephrin-A1                ligand for EPH group of receptor tyrosine
  33373_at     AL049951     -2.0    FUBP                     binds RNA; may function in control of splicing
  37624_at     M29458       -2.0    carbonic anhydrase       family members are highly tissue-specific

John-Aryankalayil, Mol Vis 2006; 12:55-64 <>
©2006 Molecular Vision <>
ISSN 1090-0535