Figure 1 of
Tada, Mol Vis 2006;
12:441-444.Figure 1 of
Tada, Mol Vis 2006;
12:441-444.
Figure 1. MERTK protein sequence of human, mouse, and rat
Black letters are the conserved residues. Leu12Pro mutation occurs at completely conserved position in human, mouse, and rat. Asterisk shows the previously reported pathogenic mutation by other groups. Red letter indicates the position that is not conserved among human, mouse and rat.
Leu12Pro
10 I 20 30 40 50 60 70 80 90 100
Human MGPAPLPLLL GLFL-PALWR RAIT-EAREE AKPYPLFPGP FPGSLQTDHT PLLSLPHASG YQPALMFSPT QPGR--P-HT GNVAIPQVTS VESKPLPPLA
Mouse MVLAPL-LL- GLLLLPALWS GG-TAEKWEE TELDQLFSGP LPGRLPVNHR PF-SAPHSSR DQ--LPP-P- QTGRSHPAHT A--A-PQVTS TASKLLPPVA
Rat MVLAPL-LL- GLLLLSALWN GG-TAEKEEE IKPDQPFSGP LPGSLPADHR PF-FAPHSSG DQ--LSP-S- QTGRSHPAHT A--T-PQMTS AASNLLPPVA
Cys115Gly
I Asn118Ser
110 120 I 130 140 150 160 170 180 190 200
Human FKHTVGHIIL SEHKGVKFNC SINVPNIYQD TT-ISWWKDG KELLGGHHRI TQFYPDDE-V TAIIASFSIT SVQRSDNGSY ICKMKINNEE IVSDPIYIEV
Mouse FNHTIGHIVL SEHKNVKFNC SINIPNTYQE TAGISWWKDG KELLGAHHSI TQFYPDEEGV S-IIALFSIA SVQRSDNGSY FCKMKVNNRE IVSDPIYVEV
Rat FKNTIGRIVL SEHKSVKFNC SINIPNVYQE TAGISWWKDG KELLGAHHSI TQFYPDEEGV S-IIALFSIT SVQRSDNGSY ICKMKVNDRE VVSDPIYVEV
Pro252Pro
I
210 220 230 240 250 260 270 280 290 300
Human QGLPHFTKQP ESMNVTRNTA FNLTCQAVGP PEPVNIFWVQ NSSRVNEQPE KSPGVLTVPG LTEMAVFSCE AHNDKGLTVS QGVQINIKAI PSPPTEVSIR
Mouse QGLPYFIKQP ESVNVTRNTA FNLTCQAVGP PEPVNIFWVQ NSSRVNEKPE RSPSVLTVPG LTETAVFSCE AHNDKGLTVS KGVHINIKVI PSPPTEVHIL
Rat QGLPYFTKQP ESVNVTRNTA FNLTCQAVGP PEPVNIFWVQ NSSRVNENPE RSPSVLTVAG LTETAVFSCE AHNDKGLTVS KGVQINIKVI PSPPTEVHIL
310 320 330 340 350 360 370 380 390 400
Human NSTAHSILIS WVPGFDGYSP FRNCSIQVKE ADPLGNGSVM IFNTSALPHL YQIKQLQALA NYSIGVSCMN EIGWSAVSPW ILASTTEGAP SVAPLNVTVF
Mouse NSTAHSILVS WVPGFDGYSP LQNCSIQVKE ADRLSNGSVM VFNTSASPHL YEIQQLQALA NYSIAVSCRN EIGWSAVSPW ILASTTEGAP SVAPLNITVF
Rat NSTAHSILVS WVPGFDGYSP LQNCSIQVKE ADQLSNGSVM VFNTSASPHL YEVQQLQALA NYSVTVSCRN EIGWSAVSPW ILASTTEGAP AVAPLNITVF
Arg466Lys
410 420 430 440 450 460 470 I 480 490 500
Human LNESSDNV-D IRWMKPPTKQ QDGELVGYRI SHVWQSAGIS KELLEEVGQN GSRARISVQV HNATCTVRIA AVTRGGVGPF SDPVKIFIPA HGWVDYAPSS
Mouse LNESN-NILD IRWTKPPIKR QDGELVGYRI SHVWESAGTV KELSEEVSQN GSWAQIPVQI HNATCTVRIA AITKGGIGPF SEPVNIIIPE HSKVDYAPSS
Rat LNESS-NNLE IRWTKPPIKR QDGELVGYRI SHVWESAGTS KELSEEVSQN GSWAQVPVQM HNATCTVRIA VITKGGIGPF SEPVDVAIPE HSRVDYAPSS
Glu540Lys*
Asn498Asn lle518Val I
I 510 520 I 530 540 550 560 570 580 590 600
Human TPAPGNADPV LIIFGCFCGF ILIGLILYIS LAIRKRVQET KFGNAFTEED SELVVNYIAK KSFCRRAIEL TLHSLGVSEE LQNKLEDVVI DRNLLILGKI
Mouse TPAPGNTDSM FIILGCFCGF ILIGLILCIS LALRRRVQET KFGGAFSEED SQLVVNYRAK KSFCRRAIEL TLQSLGVSEE LQNKLEDVVI DRNLLVLGKV
Rat TPAPGNTESM LIILGCFCGF VLMGLILYLS LAIKRRVQET KFGGAFSEED SQLVVNYRAK KSFCRRAIEL TLQSLGVSEE LQNKLEDVVV DRNLLILGKV
Arg651ter* Ser661Cys*
Ser627Ser I I
610 620 630 I 640 650 660 670 680 690 700
Human LGEGEFGSVM EGNLKQEDGT SLKVAVKTMK LDNSSHREIE EFLSEAACMK DFSHPNVIRL LGVCIEMSSQ GIPKPMVILP FMKYGDLHTY LLYSRLETGP
Mouse LGEGEFGSVM EGNLKQEDGT SQKVAVKTMK LDNFSQREIE EFLSEAACMK DFNHPNVIRL LGVCIELSSQ GIPKPMVILP FMKYGDLHTF LLYSRLNTGP
Rat LGEGEFGSVM EGNLKQEDGT SQKVAVKTMK LDNFSLREIE EFLSEAACMK DFNHPNVIRL LGVCIELSSQ GIPKPMVILP FMKYGDLHTF LLYSRIESVP
Arg722ter*
I
710 720 730 740 750 760 770 780 790 800
Human KHIPLQTLLK FMVDIALGME YLSNRNFLHR DLAARNCMLR DDMTVCVADF GLSKKIYSGD YYRQGRIAKM PVKWIAIESL ADRVYTSKSD VWAFGVTMWE
Mouse KYIHLQTLLK FMMDIAQGME YLSNRNFLHR DLAARNCMLR DDMTVCVADF GLSKKIYSGD YYRQGRIAKM PVKWIAIESL ADRVYTSKSD VWAFGVTMWE
Rat KSIPLQTLLK FMVDIAQGME YLSSRNFLHR DLAARNCMLR DDMTVCVADF GLSKKIYSGD YYRQGRIAKM PVKWIAIESL ADRVYTSKSD VWAFGVTMWE
lle871Thr*
Arg844Cys* Arg865Trp* I
810 820 830 840 850 I 860 870 I 880 I 890 900
Human IRTRGMTPYP GVQNHEMYDY LLHGHRLKQP EDCLDELYEI MYSCWRTDPL DRPTFSVLRL QLEKLLESLP DVRNQADV-- I-YVNTQLLE SSEGLAQGPT
Mouse ITTRGMTPYP GVQNHEMYDY LLHGHRLKQP EDCLDELYDI MYSCWSADPL DRPTFSVLRL QLEKLSESLP DA--Q-DKES IIYINTQLLE SCEGIANGPS
Rat IATRGMTPYP GVQNHEMYDY LLHGHRLKQP EDCLDDLYEI MYSCWSADPL DRPTFSVLRL QLEKLSESLP DA--Q-DKES IIYINTQLLE SCEGLANRSS
Arg909His
I
910 920 930 940 950 960 970 980 990 1000
Human LAPLDLNIDP DSIIASCTPR AAISVVTAEV HDSKPHEGRY ILNGGSEEWE DLTSAPSAAV TAEKNSVLPG E-RLVRNGVS WSHSSMLPLG S-SLPDELLF
Mouse LTGLDMNIDP DSIIASCTPG AAVSVVTAEV HENNLREERY ILNGGNEEWE DVSSTPFAAV TPEKDGVLP- EDRLTKNGVS WSHHSTLPLG SPS-PDELLF
Rat LAGLDMNIDP DSIIASCTAG AAVSVVMAEV HENNLHEERY ILNGGNEEWE DVASTPFATV TAGKDGVLP- EDRLTKNGIS WSHHSTLPLG SPS-PDELLF
1010 1020 1030 1040 1050
Human ADDSSEGSEV LM........ .......... .......... ..........
Mouse VDDSLEDSEV LM........ .......... .......... ..........
Rat ADDSSGDSEV LM........ .......... .......... ..........
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