Table 2 of Medvedovic, Mol Vis 2006; 12:422-440.


Table 2.

Top 50 genes with the greatest decrease in relative mRNA expression levels of regenerating lens compared to intact control lens 1, 2, and 3 weeks post-extracapsular surgery. For a better visual presentation of the regulated genes at 1, 2, and 3 weeks, the times that each gene is lowest is marked in red.

                                                                           Fold changes
 GenBank                                                 Average     ------------------------
accession                   Gene name                   expression   Week 1   Week 2   Week 3
---------   -----------------------------------------   ----------   ------   ------   ------
BC021649    cAMP responsive element binding protein 1      6892      -13.62   -18.28   -13.79
NM_153601   Glutamate-ammonia ligase                      19389      -17.18   -15.45   -11.07
NM_178922   Hypermethylated in cancer 2 protein             317       -7.66   -14.77    -8.49
AF104312    Hydroxyacid oxidase 1, liver                    129       -3.94   -14.38   -11.74
S83259      Homeobox protein NKX-2.2                       1773       -9.73   -10.93    -8.02
BC004700    Kruppel-like factor 7                         12179      -10.64   -10.48    -4.57
Y13606      Beaded filament structural protein in          6252       -7.96    -9.24    -7.53
            lens-CP94
S81982      Nitric-oxide synthase, brain                   1606       -7.95    -8.12    -4.76
M64544      Crystallin, gamma C                            4184      -15.98    -1.72    -2.21
AF349659    Thioredoxin reductase 3                        1971       -7       -6.86    -5.46
AF047542    Cytochrome P450                               13609       -4.26   -10.12    -3.32
U21110      Signal transducer and activator of             5124      -10.98    -4.58    -1.7
            transcription 5B
AJ304860    Phakinin                                        868       -5.49    -5.83    -3.85
AF309072    Lactase-like                                   1556       -4.41    -6.68    -3.57
BC025817    FAD-synthetase                                13552       -6.18    -4.78    -3.57
AJ272229    Crystallin, beta B3                           13126       -4.46    -6.07    -3.67
AF277385    Prostatic steroid binding protein C1            204       -1.11    -11.03   -1.97
AF320075    Lens fiber membrane intrinsic protein          1709       -4.89    -5.21    -3.65
AJ239052    Crystallin, beta A1                           31909       -2.24    -8.16    -2.85
NM_172635   Expressed sequence AV312086                     543       -3.68    -5.65    -3.85
AF072881    WD-40-repeat-containing protein                 930       -2.31    -5.98    -4.84
AK053869    Crystallin, beta B1                           13272       -4.78    -4.99    -3.05
U36576      Nuclear factor of activated T-cells            1711       -3.39    -5.66    -3.73
U08095      Keratin, type cytoskeletal 12                 27443       -8.61    -2.43    -1.69
AK031386    Molecule interacting with Rab13                  69        1.16    -9.99    -3.74
AF334607    Dnase2-like acid Dnase                          289       -3.9     -6.36    -2.26
AJ224342    Gamma crystallin D                            33050       -7.29    -3.29    -1.61
Z22573      Gamma crystallin B                            36961       -8.33    -1.53    -2.06
AK003904    Ars component B                               13252       -6.75    -3       -1.41
AB037890    Splicing factor 3b                             2464       -4.46    -3.59    -2.54
U03562      Heat shock protein 1                          11548       -4.09    -2.97    -3.2
AF099938    Complement component C1Q                        901       -3.38    -2.72    -3.83
AF000143    Lens fiber major intrinsic protein             2291       -2.93    -4.93    -1.76
BC032251    Brain-specific angiogenesis inhibitor 3         395       -1.76    -4.57    -3.19
K02586      Gamma crystallin A                            12401       -1.83    -5.2     -2.36
BC002008    Fatty acid binding protein 5                  14299       -3.48    -3.26    -2.42
            Mkiaa1450 Protein                               118       -2.48    -3       -3.29
            sodium shannel                                 1395       -2.99    -3.29    -2.38
BC022920    Expressed sequence AA408140                    3694       -2.22    -3.5     -2.88
AB016768    R-spondin, thrombospondin-1-like domain         123       -3.03    -3.11    -1.84
X52128      T-complex protein 11                            246       -1.71    -3.99    -2.11
AK037164    Translation initiation factor                  1597       -2.17    -2.93    -2.67
BC024653    O-acyltransferase                              2740       -1.81    -3.3     -2.4
NM_172296   Doublesex and mab-3                             386       -1.95    -2.91    -2.46
AF020772    Karyopherin (importin) alpha 3                  318       -1.15    -4.75    -1.39
L14569      Olfactory receptor 7B                            43        1.05    -5.11    -3.22
D14423      Tachykinin 2                                    572       -2.06    -3.38    -1.81
AF156979    Arrestin 3                                     2920       -2.22    -2.72    -1.8
AY158991    Small proline-rich protein 2G                   698       -1.81    -3.02    -1.86
BC012704    Carbonic anhydrase 4                           9297       -2.21    -2.63    -1.81
AF032115    DnaJ (Hsp40) homolog                           2192       -2.32    -2.55    -1.77

Medvedovic, Mol Vis 2006; 12:422-440 <http://www.molvis.org/molvis/v12/a49/>
©2006 Molecular Vision <http://www.molvis.org/molvis/>
ISSN 1090-0535