Table 2 of
Medvedovic, Mol Vis 2006;
12:422-440.
Table 2.
Top 50 genes with the greatest decrease in relative mRNA expression levels of regenerating lens compared to intact control lens 1, 2, and 3 weeks post-extracapsular surgery. For a better visual presentation of the regulated genes at 1, 2, and 3 weeks, the times that each gene is lowest is marked in red.
Fold changes GenBank Average ------------------------ accession Gene name expression Week 1 Week 2 Week 3 --------- ----------------------------------------- ---------- ------ ------ ------ BC021649 cAMP responsive element binding protein 1 6892 -13.62 -18.28 -13.79 NM_153601 Glutamate-ammonia ligase 19389 -17.18 -15.45 -11.07 NM_178922 Hypermethylated in cancer 2 protein 317 -7.66 -14.77 -8.49 AF104312 Hydroxyacid oxidase 1, liver 129 -3.94 -14.38 -11.74 S83259 Homeobox protein NKX-2.2 1773 -9.73 -10.93 -8.02 BC004700 Kruppel-like factor 7 12179 -10.64 -10.48 -4.57 Y13606 Beaded filament structural protein in 6252 -7.96 -9.24 -7.53 lens-CP94 S81982 Nitric-oxide synthase, brain 1606 -7.95 -8.12 -4.76 M64544 Crystallin, gamma C 4184 -15.98 -1.72 -2.21 AF349659 Thioredoxin reductase 3 1971 -7 -6.86 -5.46 AF047542 Cytochrome P450 13609 -4.26 -10.12 -3.32 U21110 Signal transducer and activator of 5124 -10.98 -4.58 -1.7 transcription 5B AJ304860 Phakinin 868 -5.49 -5.83 -3.85 AF309072 Lactase-like 1556 -4.41 -6.68 -3.57 BC025817 FAD-synthetase 13552 -6.18 -4.78 -3.57 AJ272229 Crystallin, beta B3 13126 -4.46 -6.07 -3.67 AF277385 Prostatic steroid binding protein C1 204 -1.11 -11.03 -1.97 AF320075 Lens fiber membrane intrinsic protein 1709 -4.89 -5.21 -3.65 AJ239052 Crystallin, beta A1 31909 -2.24 -8.16 -2.85 NM_172635 Expressed sequence AV312086 543 -3.68 -5.65 -3.85 AF072881 WD-40-repeat-containing protein 930 -2.31 -5.98 -4.84 AK053869 Crystallin, beta B1 13272 -4.78 -4.99 -3.05 U36576 Nuclear factor of activated T-cells 1711 -3.39 -5.66 -3.73 U08095 Keratin, type cytoskeletal 12 27443 -8.61 -2.43 -1.69 AK031386 Molecule interacting with Rab13 69 1.16 -9.99 -3.74 AF334607 Dnase2-like acid Dnase 289 -3.9 -6.36 -2.26 AJ224342 Gamma crystallin D 33050 -7.29 -3.29 -1.61 Z22573 Gamma crystallin B 36961 -8.33 -1.53 -2.06 AK003904 Ars component B 13252 -6.75 -3 -1.41 AB037890 Splicing factor 3b 2464 -4.46 -3.59 -2.54 U03562 Heat shock protein 1 11548 -4.09 -2.97 -3.2 AF099938 Complement component C1Q 901 -3.38 -2.72 -3.83 AF000143 Lens fiber major intrinsic protein 2291 -2.93 -4.93 -1.76 BC032251 Brain-specific angiogenesis inhibitor 3 395 -1.76 -4.57 -3.19 K02586 Gamma crystallin A 12401 -1.83 -5.2 -2.36 BC002008 Fatty acid binding protein 5 14299 -3.48 -3.26 -2.42 Mkiaa1450 Protein 118 -2.48 -3 -3.29 sodium shannel 1395 -2.99 -3.29 -2.38 BC022920 Expressed sequence AA408140 3694 -2.22 -3.5 -2.88 AB016768 R-spondin, thrombospondin-1-like domain 123 -3.03 -3.11 -1.84 X52128 T-complex protein 11 246 -1.71 -3.99 -2.11 AK037164 Translation initiation factor 1597 -2.17 -2.93 -2.67 BC024653 O-acyltransferase 2740 -1.81 -3.3 -2.4 NM_172296 Doublesex and mab-3 386 -1.95 -2.91 -2.46 AF020772 Karyopherin (importin) alpha 3 318 -1.15 -4.75 -1.39 L14569 Olfactory receptor 7B 43 1.05 -5.11 -3.22 D14423 Tachykinin 2 572 -2.06 -3.38 -1.81 AF156979 Arrestin 3 2920 -2.22 -2.72 -1.8 AY158991 Small proline-rich protein 2G 698 -1.81 -3.02 -1.86 BC012704 Carbonic anhydrase 4 9297 -2.21 -2.63 -1.81 AF032115 DnaJ (Hsp40) homolog 2192 -2.32 -2.55 -1.77 |