Table 3 of
Chen, Mol Vis 2006;
12:360-366.
Table 3. Clinical characteristics of the Pro370Leu mutation in familial glaucoma
The Pro370Leu mutation covers a wide range of population groups including French, Japanese, German, American, Greek, Indian, and Chinese. All of the published data show this mutation causes typical juvenile open angle glaucoma with characteristics of early age onset and high IOP.
Age at diagnosis (years) IOP (mm Hg) Population Familial ---------------------- ----------------------- group history Mean (range) Proband Mean (range) Proband Reference ----------- -------- ------------ ------- ------------- ------- --------- French Yes 10 (6-14) [32] 11 (7-27) Japanese Yes 21 (16-26) 16 >22 [33] German Yes <15 (25-46) [34] American Yes 12 (9-14) (35-55) [37] (French- Canadian) American Yes 6 38 [13] (English ancestry) American Yes 12 (5-27) 16 45 (25-66) 44 [14] (Caucasian) Greek Yes (9-19) 10 (20s-30s) [11] Indian Yes 17 18 (24-50) 32 [35] Chinese Yes 22.6 (14-31) 20 41 (30-54) 46 Our study |