Table 3 of Chen, Mol Vis 2006; 12:360-366.


Table 3. Clinical characteristics of the Pro370Leu mutation in familial glaucoma

The Pro370Leu mutation covers a wide range of population groups including French, Japanese, German, American, Greek, Indian, and Chinese. All of the published data show this mutation causes typical juvenile open angle glaucoma with characteristics of early age onset and high IOP.

                                 Age at
                           diagnosis (years)            IOP (mm Hg)
Population    Familial   ----------------------   -----------------------
   group      history    Mean (range)   Proband   Mean (range)    Proband   Reference
-----------   --------   ------------   -------   -------------   -------   ---------

French          Yes      10    (6-14)                                         [32]

                         11    (7-27)

Japanese        Yes      21   (16-26)     16       >22                        [33]

German          Yes      <15                          (25-46)                  [34]

American        Yes      12    (9-14)                 (35-55)                 [37]
(French-
Canadian)

American        Yes                                 6               38        [13]
(English
ancestry)

American        Yes      12    (5-27)     16       45 (25-66)       44        [14]
(Caucasian)

Greek           Yes            (9-19)     10          (20s-30s)               [11]

Indian          Yes      17               18          (24-50)       32        [35]

Chinese         Yes      22.6 (14-31)     20       41 (30-54)       46      Our study

Chen, Mol Vis 2006; 12:360-366 <http://www.molvis.org/molvis/v12/a41/>
©2006 Molecular Vision <http://www.molvis.org/molvis/>
ISSN 1090-0535