Figure 1. Pedigree with variances of MYOC

Solid symbols and open symbols represent affected and unaffected disease status, respectively. Suspects are marked with a question mark inside squares. Roman numerals and Arabian numerals indicate generations and orders. Squares and circles represent males and females, respectively. A slash across the symbol indicates a deceased family member. The arrow indicates the proband. The current age of each member is given to the right above each symbol. All sequence variants of MYOC are listed below each symbol with an asterisk indicating a heterozygous change in MYOC from C to T.