Table 1 of
Kloeckener-Gruissem, Mol Vis 2006;
12:350-355.Table 1 of
Kloeckener-Gruissem, Mol Vis 2006;
12:350-355.
Table 1. Clinical features in Wagner syndrome
Patients of the original Wagner syndrome family were assigned to the older or younger group based on the age of approximately 30 years. This age limit should be considered of gliding nature. The division into hallmark and additional features reflects our hypothesis that hallmark features represent the primary defect while additional features may be of secondary, consequential nature. More detailed information about the clinical observations can be found in the literature [4,6].
Observation in Observations in
Features Ocular symptoms younger patients older patients
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Hallmark Empty vitreous with fibrillary Frequent Not observed anymore
condensations
Avascular strands and veils Frequent Almost always
Additional Chorioretinal atrophy Frequent Always present
Rhegmatogenous retinal Rare Not observed
detachment
Peripheral tractional retinal Rare Common
detachment
Cataracts Frequent Does not apply
Visual acuity Normal to subnormal Severely affected
Refractive error Frequent mild to moderate Does not apply
myopia
Visual field Minor defects Marked field loss
Abnormal pattern of the central Rare Frequent
retinal vessels
Optic atrophy Not observed Frequent if advanced
chorioretinal atrophy
Electroretinography (ERG) dark Frequently pathologic rod Progressively
adaptation threshold frequently elevated pathologic
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