Figure 4. Effects of anti-VLA-4 and anti-VCAM-1 antibodies on passively induced EC: microphotographic evidence

Passively immunized mice developing experimental allergic conjunctivitis were treated with anti-VLA-4 antibody (C,D), anti-VCAM-1 antibody (E,F), and both antibodies (G,H) 2 h before and after short ragweed pollen challenge. Twenty-four h after the challenge, the conjunctivas were harvested for histological analysis, and eosinophils were detected by Giemsa staining. As a control, the passively immunized mice were treated with nrIgG (A,B). The scale bars represent 20 μm. The sections shown are representative of those from five different mice.