Figure 3 of Fukushima, Mol Vis 2006; 12:310-317.

Figure 3. EEffects of anti-VLA-4 and/or anti-VCAM-1 antibodies on actively induced EC

Actively immunized mice developing experimental allergic conjunctivitis were treated with anti-VLA-4 or anti-VCAM-1 antibodies 2 h before and after short ragweed pollen challenge. As the control, the mice were treated with nrIgG. Twenty-four h after the challenge, conjunctivas were harvested for histological analysis and the eosinophils were visualized by Giemsa staining. The eosinophils in the lamina propriae were counted, and the data are presented as the mean number of eosinophils/mm2. Note that compared to the nrIgG treatment, the number of eosinophils was significantly decreased by treatment with both anti-VLA-4 and anti-VCAM-1 antibodies (indicated as "both" in the image). The asterisk indicates a significant difference for the comparison of "both" treatments to nrIgG treatments (p<0.05). Error bars represent the standard error of the mean.

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