Figure 3 of
Gu, Mol Vis 2006;
12:26-31.Figure 3 of
Gu, Mol Vis 2006;
12:26-31.
Figure 3. DNA sequence chromatograms and multiple protein sequence alignments
A: DNA sequence chromatograms of the unaffected members (left) and affected members (right) in an autosomal dominant coralliform/nuclear cataract family. A single transition was observed at position 34 (C>T). B: Multiple-sequence alignment in the CRYG family and CRYGD of different species revealed that codon 14, where mutation (R14C) occurred, was located within a highly conserved region. The "Mutated" sequence indicates the sequence with the mutation detected in this Chinese family.
B
Mutated CRYGD GKITLYEDRGF QGCHYECSSD HPNLQPYLSR CNSARVDSGC 40
Homo sapiens CRYGD GKITLYEDRGF QGRHYECSSD HPNLQPYLSR CNSARVDSGC
C. familiaris CRYGD ITFYEDRGF QGRHYECSSD CPNLQPYFSR CNSIRVDSGC
Mus. musculus CRYGD GKITFYEDRGF QGRHYECSTD HSNLQPYFSR CNSVRVDSGC
R. norvegicu CRYGD GKITFYEDRGF QGRHYECSTD HSWLQPYFSR CNSVRVDSGC
Homo sapiens CRYGA GKITFYEDRDF QGRCYWCISD CPNLRVYFSR CNSIRVDSGC
Homo sapiens CRYGB GKITFYEDRAF QGRSYECTTD CPNLQPYFSR CNSIRVESGC
Homo sapiens CRYGC GKITFYEDRAF QGRSYETTTD CPNLQPYFSR CNSIRVESGC
Consensus IT YEDR F QG Y D NL Y SR CNS RV SGC
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Arg14Cys
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