Figure 5 of
Kuszak, Mol Vis 2006;
12:251-270.
Figure 5. Incorrect interpretation of secondary fiber development
The animation begins with a qualitative rendering of a generic adult lens radial cell column face (A). It is this type of drawing, based on light and scanning electron microscopic analysis of lenses from a variety of species, that has led to the notion that fibers simultaneously, rotate, migrate and elongate until they reach their sutural destinations. Indeed, if a pair of nascent differentiating fibers is highlighted (orange) in this image (B) and then presumably one step further along in their development in successive copies of the same image (C-P), then animating these images on a timeline, would appear to support the above notion. However, this interpretation is incorrect because it does not take into account the fact that lenses become larger as they grow.
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