Figure 1 of
LoGiudice, Mol Vis 2006;
12:184-189.Figure 1 of
LoGiudice, Mol Vis 2006;
12:184-189.
Figure 1. Alignment of II-III linker amino acid sequences across subunits and species
The red regions highlight amino acid motifs that are highly conserved among Cav1.3a and Cav1.3b across species. The zebrafish α1 subunits Cav1.1, Cav1.2, Cav1.4, Cav2.1, and human Cav1.4 do not share the conserved motifs.
GfCav1.3a --DAESLNTD SDDKKKGDEN EE-------- ---------- ZfCav1.3a --DAESLNT- -DDTKKPDEI DE-------- ---------- GfCav1.3b --DAESLNSA QKEE-EKRNK RKKSRSMSIY KRDG------ ZfCav1.3b --DAESLNSA QKEE-EKRNK RRKSRSMSIY KRDG------ hCav1.3 --DAESLNTA QKEEAEEKER KKIARKESLE NKKN-NKPEV ZfCav1.4 -GGDGDNK-- ---KNEEK-- -KEGE----- AEPA------ hCav1.4 SGDAGTAKDK GGEKSNEKDL PQENEGLVPG VEKE------ ZfCav1.1 --EAESLAAA QKERAEERAR KKLMKPL-PE KTEE-EKALM ZfCav1.2 --DAESLTSA QKEEEEEKER KKLARTASPE KRQNSEKPPL ZfCav2.1 --NAQELTKD EQEEEQAANK KMALQTAKEV AEVSPLSAAN GfCav1.3a ---------- ---------- ------NEED AKAGDEDEKD ZfCav1.3a ---------- ---------- ------IEDE AKAGEEDEKD GfCav1.3b ---------- ---------- ------DDGD VKASGDQEGD ZfCav1.3b ---------- ---------- ------DDRE LKAPDDQEAS hCav1.3 NQIAN----- ---------- -SDNKVTIDD YR-EEDEDKD ZfCav1.4 ---------- ---------- ------EEEN GEVK-VDMDE hCav1.4 ---------- ---------- ------EEEG ARREGADMEE ZfCav1.1 AKRLMESRQK -----TEG-M PTTAKLKIDE FESNVNEVKD ZfCav1.2 EDEKKEEKIE LKSITSDGET PTATKINIDE YTGEDNEEKN ZfCav2.1 LSIAAKEQQK NHKG------ -CKSVWEQRT SELRRQTLVN GfCav1.3a N--------A EEDEDL---- ----PDVPAG PRPM-- ZfCav1.3a N--------A EEDEEE---- ----PDVPAG PRPK-- GfCav1.3b QDQTEDVIDS SEEDEE---- --DEPEVPSG PRPPR- ZfCav1.3b RDPAEELADS SEEEEE---- --EEPEVPSG LRAQR- hCav1.3 PYPPCDVPVG EEEEEEE--- -EDEPEVPAG PRPRR- ZfCav1.4 EYE------E EEEPEE---- ----GDDEE- ------ hCav1.4 EEE------E EEEEEE---- ----EEEEEG AGGVEL ZfCav1.1 PFPPADFP-G DDEEEE---- ----PEIPIS PRPRP- ZfCav1.2 PYPVNDFPAG EDDEEE---- ----PEMPVG PRPRP- ZfCav2.1 SREALYNELD PEDRWKVSYS RHIRPDMKTH LDRPL- |