Table 5. Relationship between the p53 gene mutation and BPDE-like DNA adduct levels

Fisher's exact test was used for statistical analysis. The results were evaluated independently by three observers and scored for the percentage of positive nuclei: A score of - or low meant from 0% to 10%; a score of + or high demonstrated more than 11% positive cells. Mutations analyzed in this study were based on mutations found in prior pterygium samples (Tsai et al. [16]).

              BPDE-like DNA
              adduct levels
p53 gene   --------------------
mutation   Low   High   p-value
--------   ---   ----   -------
Negative   37     6
Positive    5     3      0.137