Figure 8. Time-dependent secretion of vascular endothelial growth factor-A in polarized ARPE-19 monolayers after 150 μM t-butylhydroperoxide treatment

Apical and basolateral vascular endothelial growth factor-A (VEGF-A) secretion increased as a function of time of tBH treatment with maximal increase at 5 h (p<0.05 versus controls). Figure also shows VEGF-A secretion in untreated controls on the apical (dotted line) and basolateral (open circles). Data are mean±SEM from 3-4-determinations/time point.