Table 2 of
Horie, Mol Vis 2006;
12:1601-1605.Table 2 of
Horie, Mol Vis 2006;
12:1601-1605.
Table 2. Genotype frequency of VKH patients and healthy controls at tyrosinase gene family loci
Chr represents Chromosome. R.R. represents relative risk. Pc represents corrected P-values by Bonferroni's correction.
VKH patients Healthy controls
Allele ----------------- -----------------
Chromosome Marker size (2n=174) (%) (2n=244) (%) R.R. P Pc
---------- --------- ------ -------- ------ -------- ------ ---- ---- -----
Chr 9
D9S0128i 257 2 (1.1) 0 (0.0) 0.00 0.09 0.65
259 117 (67.2) 178 (73.0) 0.76 0.21 1.45
261 1 (0.6) 3 (1.2) 0.46 0.50 3.49
263 0 (0.0) 1 (0.4) 0.00 0.40 2.79
265 9 (5.1) 5 (2.0) 2.61 0.08 0.56
267 33 (19.0) 40 (16.4) 1.19 0.50 3.46
269 12 (6.9) 17 (7.0) 0.99 0.98 6.84
D9S0926i 297 0 (0.0) 1 (0.4) 0.00 0.40 4.77
301 15 (8.6) 13 (5.3) 1.68 0.18 2.21
303 2 (1.1) 0 (0.0) 0.00 0.09 1.12
305 0 (0.0) 1 (0.4) 0.00 0.40 4.77
307 4 (2.3) 8 (3.3) 0.40 0.13 1.55
309 10 (5.7) 9 (3.7) 0.91 0.85 10.21
311 46 (26.4) 60 (24.6) 1.10 0.67 8.03
313 86 (49.4) 140 (57.4) 0.73 0.11 1.29
315 7 (4.0) 7 (2.9) 1.42 0.52 6.22
317 3 (1.7) 4 (1.6) 1.05 0.95 11.36
319 0 (0.0) 1 (0.4) 0.00 0.40 4.77
321 1 (0.6) 0 (0.0) 0.00 0.24 2.83
D9S267 158 0 (0.0) 1 (0.4) 0.00 0.40 3.98
160 14 (8.0) 14 (5.7) 1.44 0.35 3.52
162 96 (55.1) 159 (65.2) 0.66 0.04 0.39
164 6 (3.4) 11 (4.5) 0.76 0.59 5.89
166 3 (1.7) 5 (2.0) 0.84 0.81 8.11
168 9 (5.2) 4 (1.6) 3.27 0.04 0.40
170 41 (23.6) 45 (18.4) 1.38 0.19 1.87
172 4 (2.3) 3 (1.2) 1.89 0.40 4.01
174 1 (0.6) 0 (0.0) 0.00 0.24 2.36
178 0 (0.0) 2 (0.8) 0.00 0.23 2.31
Chr 11
D11S0529i 404 1 (0.6) 0 (0.0) 0.00 0.24 2.36
408 1 (0.6) 2 (0.8) 0.70 0.77 7.70
410 1 (0.6) 3 (1.2) 0.46 0.50 4.98
412 18 (10.3) 20 (8.2) 1.29 0.45 4.51
414 50 (28.7) 60 (24.6) 1.24 0.34 3.43
416 56 (32.2) 83 (34.0) 0.92 0.70 6.95
418 16 (9.2) 32 (13.1) 0.67 0.22 2.15
420 28 (16.1) 40 (16.4) 0.98 0.93 9.34
422 3 (1.7) 3 (1.2) 1.41 0.68 6.75
424 0 (0.0) 1 (0.4) 0.00 0.40 3.98
D11S0260i 232 25 (14.4) 32 (13.1) 1.11 0.71 4.28
234 20 (11.5) 38 (15.6) 0.70 0.23 1.41
236 56 (32.2) 59 (24.1) 1.49 0.07 0.43
238 70 (40.2) 108 (44.3) 0.85 0.41 2.47
240 2 (1.1) 4 (1.6) 0.70 0.68 4.07
242 1 (0.6) 3 (1.2) 0.46 0.50 2.99
Chr 13
D13S0450 383 0 (0.0) 1 (0.4) 0.00 0.40 3.98
387 32 (18.4) 51 (20.9) 0.85 0.53 5.26
389 1 (0.6) 6 (2.5) 0.23 0.14 1.39
391 2 (1.1) 0 (0.0) 0.00 0.09 0.93
393 41 (23.6) 43 (17.6) 1.44 0.14 1.35
395 67 (38.5) 107 (43.9) 0.80 0.27 2.74
397 15 (8.6) 21 (8.6) 1.00 1.00 9.96
399 15 (8.6) 10 (4.1) 2.21 0.06 0.55
401 1 (0.6) 4 (1.6) 0.35 0.32 3.24
403 0 (0.0) 1 (0.4) 0.00 0.40 3.98
D13S0504 426 6 (3.4) 11 (4.5) 0.76 0.59 4.12
430 31 (17.8) 53 (21.7) 0.78 0.33 2.28
434 85 (48.9) 110 (45.1) 1.16 0.45 3.13
438 31 (17.8) 38 (15.6) 1.18 0.54 3.80
442 12 (6.9) 27 (11.1) 0.60 0.15 1.04
446 7 (4.0) 5 (2.0) 2.00 0.23 1.64
450 2 (1.1) 0 (0.0) 0.00 0.09 0.65
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