Figure 2 of
Nickerson, Mol Vis 2006;
12:1565-1585.
Figure 2. Alignment and comparison of Donor and Acceptor sites from the tetrapods
This is a comparison to the accepted consensus donor and acceptor sites from human genes. All the introns contain invariant GT and AG dinucleotides at the beginning and end of the intron. Most nearby nucleotides closely match the consensus donor or acceptor motif. The lariat consensus sequence is detected in about half the introns within 50 nucleotides of the acceptor site, and all have several A's, which may function in the absence of a closely matching lariat sequence. These alignments indicate that the splice sites are all strongly conserved in position and sequence, and they all appear to function well.
Donor Acceptor Exon | Intron Intron | Exon Exon 1/Intron A/Exon 2 chimp GCCCATGCAG GTGAGACCCAAGAGA TAAAACTGGCTGCTCCTCCTGACACTGAGTAGGACCTCCACCTCTTACAG ATCCCTTCCC human GCCCATGCAG GTGAGACCCAAGAGA TAAAACTGGCTGCTCCTCCTGACACTGAGTAGGACCTCCAACTCTTACAG ATCCCTTCCC cow ACCCATGCAG GTGAGTCACAAGGGA CTTTCAAATCTTTCCTTTCCTGACATGGAGCTGACCTCCCACTCTTTCAG ATCCCTTCCC dog GCCCATGCAG GTGAGACACGCGGTC CCTGTGCCCGGGCTGAGTGGAGCCCCGCAGCCCCTGCCCTGCTCTTGCAG ATTCCCTCCC rat GCCCATGCAG GTAAGGTACAAGAGA CCATACCCACCCCACTCCCAGGCACTGCCTGACTCTTCCCTCTCTTCCAG ATTCCCTCCC mouse GCCCATGCAG GTAAGGTACAACAGA CGGCCATCTGCTGCTGTCCTGATACTGAGCCAGGCTTCCCACTCTTGCAG ATTCCCTCCC opposum ATGCAGGTGA GTCTCCAAAACAGCC GAAGGAATGCGTTCCATGACTTTTCCAACTTTAATTTGAATTTTTGTCAG CTTCCCTCTC chicken GCCAAAACAG GTACAGTTTTTTTTT AGCTATCAGTGCCAGCAAATGATTTGTTTTGTTTTTCCAAACTCTTTCAG ATCCCTTCCC Xen. Trop GCCAATGCAG GTATGTAAAGTTTTA TTTCTACCAGTTTTTACATGTGCTAAAAATCTGCTTCTCAATCCTTTTAG ATCCCATCAC Exon 2/Intron B/Exon 3 chimp TCGACATGAG GTCAGTGGCCAGGGG GCCTCACTGTGAGCTCAGCCCCTGAACAGGCTCTGCTTCCCATCCTTCAG GTTCAACATC human TCGACATGAG GTCAGTGGCCAGGGG GCCTCACTGTGAGCTCAGCCCCTGAACAGGCTCTGCTTCCCATCCTTCAG GTTCAACATC cow TCGACATGAG GTCAGTGGGCCTGAG GCTTCCCTGTGGGTTCTGCCCCTTAGTGGGCAACTTTTCCCTTCCTTCAG GTTCAACATC dog TCGACATGAG GTCAGAGTCAGGGGG GGCCGCCCCATCAGCCCCTGCCCCCAGCGGTCCCACTTCTCTCCCCGCAG GTTCAACATC rat TCGACATGAG GTCAGTGGGCTAGAC TTGAGTGCCTCTCAGACCACCCTCAGAGTCATTGTCTCTGCCTCCCTTAG ATTTAACATC mouse TCGACATGAG GTCAGTGGGCTGGAC CTCCCTGTGAGCTCAGACGCCCTCCGAGTCATTGGCTCTGCTTCCCTTAG GTTCAACCTT opposum TTGATATGAG GTAAACATGGGAGGG TCAGGGAGCTTTAATTTGGTTTCTAATGCTCACTAGTTCATGCCCAACAG GTTCAACATA chicken TAGACATGAG GTAAACCTTTGAATG AGCTATCAGTGCCAGCAAATGATTTGTTTTGTTTTTCCAAACTCTTTCAG ATCCCTTCCC Xen. Trop TTGATATGAG GTAGGTTGTCATTTC TAATATAAAATAAGACTTATATTCAACAACATTTATTGTTTACATTTCAG ATTTAACATC Exon 3/Intron C/Exon 4 chimp CAGGTTGTAG GTACGTGGAGAAGCT CTCCAGGGTCCTGACATGACCCCCATCCTGAAGGGCCTTCTGTCTTCCAG GTGAACGCTA human CAGGTTGTAG GTACGTGGAGAAGCT CTCCAGGGTCCTGACATGACCCCCATCCTGAAGGGCCTTATGTCTTCCAG GTGAACGCTA cow CAGCTTGAAG GTGCGTGCAGAAGGC CCCAGCGTGGGGATTTGACTCCCTATTTTGAAGGGTCTTGTATCTTGCAG GTGAACGCTA dog GACTCTGTCA GTGAGCTCTGGACCC CAGGGGCCCCGGGGACTGCCAGCCGGCTTGAAGGGCCCTGTGTCTTGCAG GTGAGCGCTA rat CAGCTCACAG GTACATGAAGCCTTC GGTGGGAGGGTATTCATTTGGCCCCATGCTGAATGGCCTCTGTCCTCCAG GTGAACGATA mouse CAGCTCACAG GTACCTGAAGCCTTC AGGTGGCGGGGGCTGATTTGACCCCGTGCTGAATGGCCTCTGTCCTCCAG GTGAACGATA opposum ACAGTCTCAG GTTGCAGGTGAGAGG CAATTACAGTCCTCCAGAATCTTATATTCTGTCAATTTTGTCTCTTGCAG GTGAACGATA chicken TAGACATGAG GTAAACCTTTGAATG AATCTCTGAAAATGGTGAAATTTTGTGATGCTTTTTGTCCTTTACGGCAG GGGAGAGGTA Xen. Trop CATCTTGTAG GTATGTAAGTGCACA TATTCATTTAAATTTATACCGCTGGATGTGCTTATTTTTTCCCTACACAG GAAATGCTTT Consensus CAR GTRAGT... ...YYYYYYYYYYYNYAG G |