Figure 1 of
Rivolta, Mol Vis 2006;
12:1511-1515.Figure 1 of
Rivolta, Mol Vis 2006;
12:1511-1515.
Figure 1. Consequences of the Cys98Tyr change on the putative Cys98-Cys175 disulfide bridge of peropsin
The figure shows the putative 3D structure of peropsin, as modeled on crystallographic data from rhodopsin [16]. According to what is currently known about opsins and their structural features, peropsin's residues Cys98 and Cys175 (green stripes) should be connected by a disulfide bond (yellow arrow). The Cys98Tyr (TGT->TAT) mutant observed in a patient with retinitis punctata albescens would eliminate this bond and could potentially compromise the structure and function of the protein.
