Table 3 of
Stambolian, Mol Vis 2006;
12:1499-1505.Table 3 of
Stambolian, Mol Vis 2006;
12:1499-1505.
Table 3. Combined heterogeneity LOD scores using multipoint family LOD scores from both genome screens
Combined HLOD data (44 families from previous genome scan and 19 families from current scan) support location of a locus for common myopia to 22q11.2. HLOD scores were calculated assuming that penetrance of the dominant risk allele is 0.9 and the phenocopy rate is 0.10. Megabase locations from the UCSC Genome Browser (March, 2006 assembly) and the Marshfield Genetic map are provided for reference.
Results at loci Results at loci
with combined from previous
analysis genome screen
Genetic (63 families) (44 families)
map ---------------- ---------------
Nearest Megabase (Kosambi Combined
Chromosome marker location cM) HLOD Alpha HLOD Alpha
---------- -------- --------- -------- -------- ----- ---- -----
8p22 GAAT1A4 99258915 110.2 0.31 0.11 1.17 0.19
11q23 D11S912 128129303 131.26 0.73 0.16 1.24 0.19
13q22 D13S317 81620034 63.9 1.38 0.22 1.43 0.26
14q32 D14S1426 99689318 125.88 1.53 0.31 1.29 0.34
15q26 D15S642 100152295 122.14 1.65 0.4 0 0
22q11.2 D22S685 100152295 32.39 4.73 0.38 3.54 0.4
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