Figure 1 of Okamoto, Mol Vis 2006; 12:156-158.


Figure 1. Association analysis of Complement Factor H haplotypes

A: Four sets of single nucleotide polymorphisms (SNPs; I62V, IVS6, Y402H, Q672Q) were selected to distinguish all five haplotypes reported [6]. B: All haplotypes with a frequency >3% are displayed. The estimated frequencies for Japanese (JP) and American (US) cases and controls in these risk and protective haplotypes are shown (JP/US). The red "C" represents the nucleotide responsible for the Y402H polymorphism. N/A means "not available."

A:

(6 K)

B:

                           Estimated frequencies
                         -------------------------    Risk (R) or
                            Cases       Controls     protective (P)
                         -----------   -----------     likelihood
  Haplotypes       p      JP     US     JP     US     (fold JP/US)
--------------   -----   ----   ----   ----   ----   --------------
H1: G  T  T  G   1.000   0.38   N/A    0.38   N/A         1.0/-
H2: A  T  T  A   0.001   0.18   0.12   0.35   0.21    (P) 1.6/1.7
H3: G  T  T  A   0.028   0.19   N/A    0.10   N/A     (R) 1.9/-
H4: A  T  T  C   0.004   0.15   N/A    0.06   N/A     (R) 2.5/-
H5: G  T  C  A   0.802   0.04   0.50   0.04   0.29    (R) 1.0/1.7

Okamoto, Mol Vis 2006; 12:156-158 <http://www.molvis.org/molvis/v12/a17/>
©2006 Molecular Vision <http://www.molvis.org/molvis/>
ISSN 1090-0535