Table 3 of
Rozsa, Mol Vis 2006;
12:125-141.
Table 3. 111 Differential dexamethasone-induced gene expression in trabecular meshwork, sorted by functional categories
The table lists the GenBank accession number, gene name, fold change within each individual TM cell line and the average of all three cell lines for 111 genes with three fold or greater change in expression determined by microarray analysis. Fold change is relative to untreated cells. Genes are sorted according to functional category.
HTM A HTM B HTM C Mean GenBank Gene title (Symbol) fold fold fold fold --------- ----------------------------------------------------------- ----- ----- ----- ----- Adhesion NM_004791 integrin, β-like 1 (IGBL1) 8.4 4.4 7.5 6.4 M35999 integrin, β3 (ITGB3) 4.7 3.2 4.4 3.9 BC003610 milk fat globule-EGF factor 8 protein (MFGE8) 2.8 2.2 5.7 3.3 AW188198 tumor necrosis factor, α-induced protein 6 (TNFAIP6) -5.1 -6.8 -1.9 -3.8 Cytokine NM_000600 interleukin 6 (IL6) -4.1 -3.1 -4.1 -3.7 NM_002309 leukemia inhibitory factor (LIF) -7.6 -5.8 -7.1 -6.8 Cytoskeleton NM_001615 actin, γ2, smooth muscle, enteric (ACTG2) 2.9 19.2 4.2 9.4 AV712733 filamin B, β (FLNB) 4.2 3.5 6.8 4.8 NM_001613 actin, α2, smooth muscle, aorta (ACTA2) 4.8 4.1 5.2 4.6 AL157398 nebulette (NEBL) 3.3 4.9 7.2 4.4 AL136139 neural precursor cell expressed, developmentally 4.7 3.0 6.2 4.3 downregulated 9 (NEDD9) NM_003186 transgelin (TAGLN) 3.4 3.4 4.8 3.5 Enzyme NM_004117 FK506 binding protein 5 (FKBP5) 104.4 19.3 12.4 19.9 AA923354 monoamine oxidase A (MAOA) 17.1 13.3 9.6 13.1 NM_002150 4-hydroxyphenylpyruvate dioxygenase (HPD) 14.4 5.4 13.3 11.9 NM_002862 phosphorylase, glycogen; brain (PYGB) 8.9 5.4 21.0 6.9 AB046692 aldehyde oxidase 1 (AOX1) 5.4 3.4 6.8 5.5 NM_018063 helicase, lymphoid-specific (HELLS) 6.3 3.8 1.3 4.0 NM_021154 phosphoserine aminotransferase 1 (PSAT1) 5.0 4.7 2.2 3.8 NM_016341 phospholipase C, epsilon 1 (PLCE1) 5.0 2.4 3.3 3.6 NM_014863 B cell RAG associated protein (GALNAC4S-6ST) 5.5 2.3 2.9 3.3 AI479175 sulfatase 1 (SULF1) -1.5 -6.1 -5.5 -3.0 NM_018371 chondroitin β1,4 N-acetylgalactosaminyltransferase -2.4 -4.0 -2.4 -3.2 (ChGn) NM_000691 aldehyde dehydrogenase 3 family, member A1 (ALDH3A1) -5.0 -5.9 -2.3 -3.3 NM_005019 phosphodiesterase 1A, calmodulin-dependent (PDE1A) -2.9 -5.8 -2.7 -3.8 NM_000962 prostaglandin-endoperoxide synthase 1 (PTGS1) -4.1 -4.5 -3.8 -4.3 AJ251847 chitinase 3-like 1 (CHI3L1) -6.1 -7.2 -5.0 -6.1 Extracellular matrix AI806793 collagen, type VIII, α2 (COL8A2) 6.9 2.0 5.3 4.2 NM_002380 matrilin 2 (MATN2) -3.0 -7.1 -2.8 -3.7 NM_002345 lumican (LUM) -6.7 -6.2 -3.3 -4.8 Growth factor X07868 putative insulin-like growth factor II associated protein 9.5 13.1 5.2 7.8 (IGF2) AA583044 bone morphogenetic protein 2 (BMP2) -3.8 -4.0 -3.3 -3.6 X16323 hepatocyte growth factor (hepapoietin A; scatter factor) -5.6 -3.5 -3.9 -4.2 (HGF) M13436 inhibin, β A (INHBA) -4.2 -5.3 -4.2 -4.8 NM_002091 gastrin-releasing peptide (GRP) -7.2 -7.5 -7.4 -6.8 AF003934 growth differentiation factor 15 (GDF15) -6.3 -10.5 -6.9 -7.3 NM_000266 Norrie disease (NDP) -13.0 -4.5 -5.8 -7.7 AI972496 insulin-like growth factor 1 (IGF1) -12.3 -16.9 -6.4 -13.1 Ion transport NM_000219 potassium voltage-gated channel, Isk-related family, member 8.1 2.3 2.0 4.2 1 (KCNE1) AA551075 potassium channel tetramerization domain containing 12 3.0 3.9 2.9 3.3 (KCTD12) NM_002246 potassium channel, subfamily K, member 3 (KCNK3) -2.3 -5.2 -3.3 -3.0 NM_024505 NADPH oxidase, EF-hand calcium binding domain 5 (NOX5) -2.7 -3.0 -3.4 -3.0 NM_000812 gamma-aminobutyric acid (GABA) A receptor, β1 (GABRB1) -3.3 -2.6 -3.8 -3.2 AB040120 solute carrier family 39 (zinc transporter), member 8 -7.8 -2.0 -4.4 -4.3 (SLC39A8) NM_000096 ceruloplasmin (CP) -4.0 -4.8 -3.7 -4.3 U73191 potassium inwardly rectifying channel, subfamily J, member -7.9 -7.5 -10.9 -8.8 15 (KCNJ15) Kinase NM_004438 EPH receptor A4 (EPHA4) 3.9 7.6 12.2 6.4 NM_022740 homeodomain interacting protein kinase 2 (HIPK2) 5.0 4.1 3.8 4.3 NM_030751 SNF1-like kinase (SNF1LK) 5.3 2.7 3.9 3.9 AI992251 ribosomal protein S6 kinase, 90 kDa, polypeptide 2 4.0 2.4 3.2 3.3 (RPS6KA2) Metallothionein R06655 metallothionein 1M (MT1M) 14.1 3.5 10.3 8.9 NM_002450 metallothionein 1X (MT1X) 3.4 4.3 3.3 3.7 Peptidase NM_001710 B-factor, properdin (BF) -3.9 -3.6 -2.4 -3.3 NM_002421 matrix metalloproteinase 1 (MMP1) -4.9 -2.7 -14.1 -4.4 NM_007038 a disintegrin-like and metalloprotease with thrombospondin -2.7 -6.7 -3.4 -4.4 type 1 motif, 5 (ADAMTS5) BC006393 carboxypeptidase Z (CPZ) -2.7 -13.8 -3.7 -4.8 NM_000439 proprotein convertase subtilisin/kexin type 1 (PCSK1) -16.3 -8.3 -11.9 -11.7 Phosphatase AW009884 protein phosphatase 2 (formerly 2A), regulatory subunit A, -2.4 -6.5 -5.1 -3.3 β isoform (PPP2R1B) Protease inhibitor NM_001085 serine (or cysteine) proteinase inhibitor, clade A, member 86.0 31.2 52.2 48.2 3 (SERPINA3) NM_003064 secretory leukocyte protease inhibitor (SLPI) 24.9 6.3 62.8 34.2 NM_000062 serine (or cysteine) proteinase inhibitor, clade G, member 4.7 2.1 3.8 3.9 1 (SERPING1) Proteasome NM_018324 thioesterase domain containing 1 (THEDC1) 3.1 4.0 2.6 3.2 D42055 neural precursor cell expressed, developmentally 1.8 2.1 4.4 3.0 down regulated 4 (NEDD4) Receptor NM_001993 coagulation factor III (F3) 11.3 47.5 26.7 26.2 NM_004633 interleukin 1 receptor, type II (IL1R2) 9.0 58.1 26.9 22.9 NM_014879 purinergic receptor P2Y, G-protein coupled, 14 (P2RY14) 12.4 4.8 6.4 7.5 NM_002029 formyl peptide receptor 1 (FPR1) 6.9 1.1 4.8 3.9 AF064826 glypican 4 (GPC4) 4.7 2.4 4.8 3.7 NM_000361 thrombomodulin (THBD) 3.7 3.7 1.6 3.0 NM_030781 collectin subfamily member 12 (COLEC12) -2.2 -5.4 -2.3 -3.0 AY029180 plasminogen activator, urokinase receptor (PLAUR) -6.2 -2.0 -4.0 -3.5 NM_002546 tumor necrosis factor receptor superfamily, member 11b -12.6 -7.9 -4.0 -6.6 (TNFRSF11B) NM_001338 Coxsackie virus and adenovirus receptor (CXADR) -4.4 -8.9 -8.0 -7.2 Transcription NM_006006 zinc finger and BTB domain containing 16 (ZBTB16) 13.5 14.8 12.3 13.6 AL110191 TSC22 domain family, member 3 (TSC22D3) 6.9 6.2 6.9 6.8 NM_002616 period homolog 1 (PER1) 3.8 3.2 3.2 3.4 NM_015559 SET binding protein 1 (SETBP1) 3.0 2.5 4.8 3.3 NM_004143 Cbp/p300-interacting transactivator, with Glu/Asp-rich -1.1 -5.6 -4.6 -3.3 carboxy-terminal domain, 1 (CITED1) BF514079 Kruppel-like factor 4 (gut, KLF4) -2.9 -2.4 -5.0 -3.3 NM_016831 period homolog 3 (PER3) -2.8 -4.9 -4.4 -3.8 U12767 nuclear receptor subfamily 4, group A, member 3 (NR4A3) -5.3 -11.5 -1.9 -3.8 AI360875 SRY (sex determining region Y)-box 11 (SOX11) -2.2 -2.6 -7.2 -3.9 Transport M10906 serum amyloid A1 (SAA1) 333.4 37.4 252.9 218.7 NM_030754 serum amyloid A2 (SAA2) 180.2 17.9 145.6 114.0 NM_000275 oculocutaneous albinism II (OCA2) 7.3 2.1 7.6 5.5 NM_001647 apolipoprotein D (APOD) 14.8 4.0 10.6 5.3 BF447105 sortilin 1 (SORT1) 3.0 2.0 4.1 3.0 NM_001878 cellular retinoic acid binding protein 2 (CRABP2) -2.1 -4.3 -2.3 -3.1 NM_003469 secretogranin II (SCG2) -3.7 -2.9 -4.8 -3.7 Other NM_021146 angiopoietin-like 7 (ANGPTL7) 271.9 65.0 116.4 187.0 D88214 myocilin, trabecular meshwork-inducible glucocorticoid 64.8 7.7 54.8 16.7 response (MYOC) NM_014059 response gene to complement 32 (RGC32) 64.6 22.4 8.2 12.3 AL136861 cysteine-rich secretory protein LCCL domain containing 2 20.9 5.5 7.5 10.6 (CRISPLD2) NM_015385 sorbin and SH3 domain containing 1 (SORBS1) 11.9 2.5 7.7 6.3 AL050264 TU3A protein (TU3A) 4.7 2.5 6.9 4.4 NM_016109 angiopoietin-like 4 (ANGPTL4) 2.3 8.0 2.9 4.1 NM_002923 regulator of G-protein signaling 2, 24 kDa (RGS2) 2.5 2.7 4.4 3.1 AA243659 Family with sequence similarity 49, member A (FAM49A) 2.7 4.1 2.7 3.1 AB020690 paraneoplastic antigen MA2 (PNMA2) 3.0 2.2 3.2 3.1 NM_006444 SMC2 structural maintenance of chromosomes 2-like 1 (yeast) -3.0 -2.7 -3.3 -3.1 (SMC2L1) BC005961 parathyroid hormone-like hormone (PTHLH) -1.5 -14.0 -3.5 -3.3 NM_024780 transmembrane channel-like 5 (TMC5) -3.2 -1.7 -5.7 -3.5 NM_015564 leucine rich repeat transmembrane neuronal 2 (LRRTM2) -3.3 -2.8 -5.8 -3.6 AF338650 PDZ domain containing 3 (PDZK3) -6.3 -2.6 -5.4 -4.0 NM_005101 interferon, alpha-inducible protein (clone IFI-15K, G1P2) -7.0 -2.6 -1.8 -4.0 NM_003810 tumor necrosis factor (ligand) superfamily, member 10 -2.7 -7.1 -3.9 -4.4 (TNFSF10) AI074333 angiopoietin-like 2 (ANGPTL2) -3.7 -8.6 -2.8 -4.4 NM_005863 neuroepithelial cell transforming gene 1 (NET1) -3.0 -7.0 -3.0 -4.4 NM_014890 downregulated in ovarian cancer 1 (DOC1) -7.3 -5.8 -4.6 -5.9 NM_013409 follistatin (FST) -13.5 -7.1 -6.9 -8.7 AB024518 chromosome 9 open reading frame 26 (C9orf26) -3.2 -12.7 -33.7 -17.1 |