Table 2 of
Kompella, Mol Vis 2006;
12:1185-1198.
Table 2.
Nanoparticle uptake into various layers of bovine cornea in the bovine ex vivo model. The data are expressed as mean±SD for n=3. ND; Not detectable. Tissue weights with epithelium were measured at time zero and those without epithelium were measured at the end of 60 min incubation. Note that there are no significant differences in the weights of stroma and endothelium between the two groups. A dosing solution of 10 mg/ml nanoparticles at 50 μl volume was used. All other studies employed 1 mg/ml concentration.
Tissue Tissue NP uptake at 5 min (%) NP uptake at 60 min (%) weight (g) weight (g) ----------------------- ----------------------- (with (without With Without With Without Corneal layer epithelium) epithelium) epithelium epithelium epithelium epithelium ------------- ------------ ------------ ---------- ---------- ---------- ---------- Epithelium 0.0627±0.002 - 1.60 - 1.31 - Stroma 0.5139±0.021 0.5601±0.038 0.45 22.54 0.63 21.56 Endothelium 0.0083±0.001 0.0086±0.001 ND 0.039 ND 0.143 |