Figure 5.

Schematic representation of the PAX3 homeodomain, together with structural features based on the three-dimensional structure of the homeodomain of the Drosophila Prd protein (α, α-helix) is shown [29]. The amino acid sequence for positions 1-61 of the Pax-3 homeodomain is shown, and invariant residues among this class of homeodomain [33] are identified below. The position and nature of the mutation introduced in Pax-3 is shown in red. The systematic nomenclature of the mutants with respect to their position within the homeodomain and the substitution involved are shown to the left.