Table 5 of
Cai, Mol Vis 2006;
12:1-14.Table 5 of
Cai, Mol Vis 2006;
12:1-14.
Table 5. Genes within ARPE19 upregulated genes >three fold compared to adult human RPE (ahRPE)
Data were generated from Affymetrix U95Av2 DNA microarray analysis of four ahRPE and five ARPE19 samples. Numbers shown in ahRPE and ARPE19 columns are the mean values of DNA microarray chip densitometry scan signals. Numbers shown in ahRPE/ARPE19 column are fold-changes comparing ahRPE gene expression level with ARPE19. Numbers in p value column are from student t-test. Asterisk indicates genes within 2,500 most abundant gene list.
ARPE19/
Gene title Symbol ARPE19 ahRPE ahRPE p value Gene functions
--------------------------------- --------- ------ ----- ------- -------- --------------------
N-myristoyltransferase 2 NMT2 594.9 106.6 5.6 0.000001 N-terminal protein
myristoylation;
protein-lipoylation
ectonucleotide ENPP2 1604.2 319.5 5.0 0.000004 phosphate
pyrophosphatase/phosphodiesterase metabolism; cell
2 motility
interleukin 18 IL18 710.7 157.9 4.5 0.000572 angiogenesis;
(interferon-γ-inducing immune response;
factor) apoptosis; cell
adhesion
V-erb-a erythroblastic leukemia ERBB4 249.5 57.6 4.3 0.000001 protein
viral oncogene homolog 4 phosphorylation;
cell proliferation
IGF-II mRNA-binding protein 3 IMP-3 440.5 108.1 4.1 0.000273 RNA processing;
protein
biosynthesis;
morphogenesis
glypican 3 GPC3 695.2 173.8 4.0 0.001307 morphogenesis
ferredoxin reductase FDXR 1152.5 289.2 4.0 0.000003 electron transport;
steroid
biosynthesis
v-jun sarcoma virus 17 oncogene JUN 345.9 88.3 3.9 0.001689 regulation of
homolog (avian) transcription,
DNA-dependent
bromodomain adjacent to zinc BAZ2A 538.9 142.3 3.8 0.001987 chromatin
finger domain, 2A remodeling;
regulation of
transcription
kinesin family member 5C KIF5C 407.4 108.0 3.8 0.000937 microtubule-based
movement
regulator of G-protein signalling RGS20 468.5 126.9 3.7 0.000192 signal transduction
20
damage-specific DNA binding DDB2 796.8 217.7 3.7 0.000000 nucleotide-excision
protein 2, 48 kDa repair
protein kinase C, β 1 PRKCB1 514.4 141.0 3.6 0.001343 protein
phosphorylation;
intracellular
signaling cascade
phosphoribosyl pyrophosphate PRPSAP1 824.8 230.3 3.6 0.000000 nucleoside
synthetase-associated protein 1 metabolism;
nucleotide
biosynthesis
protein kinase C, α PRKCA 430.2 122.2 3.5 0.000008 protein
phosphorylation;
induction of
apoptosis
chromosome 6 open reading frame C6orf111 94.8 27.0 3.5 0.000054 unknown
111
cystathionine-β CBS 222.7 64.3 3.5 0.000249 amino acid
biosynthesis;
metabolism
discs, large homolog 1 DLG1 113.4 32.8 3.5 0.004625 guanylate kinase
(Drosophila) activity;
cytoskeletal
protein binding
heterogeneous nuclear HNRPA3 194.8 56.4 3.5 0.010911 RNA binding;
ribonucleoprotein A3 ribonucleoprotein
complex
cyclin H CCNH 1135.8 333.4 3.4 0.000227 regulation protein
kinase activity;
cell cycle
HERV-H LTR-associating 1 HHLA1 1139.2 335.0 3.4 0.000619 human endogenous
retrovirus
actin, α 2, smooth muscle, ACTA2 1572.9 466.2 3.4 0.000000 muscle development
aorta
growth arrest and GADD45A 725.9 215.7 3.4 0.000204 regulation of
DNA-damage-inducible, α protein kinase
activity;
apoptosis
KIAA0179 KIAA0179 519.2 155.7 3.3 0.000021 rRNA processing;
superoxide
metabolism
Purkinje cell protein 4 PCP4 1231.5 372.1 3.3 0.003288 central nervous
system development
cytochrome b-245, α polypeptide CYBA 2015.6 612.7 3.3 0.000000 electron transport;
superoxide
metabolism
DNA segment on chromosome X and Y DXYS155E 480.4 146.6 3.3 0.001093 regulation of
transcription,
signal transduction
angiomotin like 2 AMOTL2 830.0 255.2 3.3 0.000036 regulation of
visceral endoderm
movement
heterogeneous nuclear HNRPA1 1233.9 381.2 3.2 0.000020 mRNA processing;
ribonucleoprotein A1 transport
reelin RELN 353.7 109.4 3.2 0.000597 cell adhesion;
development
cordon-bleu homolog (mouse) COBL 214.8 66.5 3.2 0.000007 unknown
transforming growth factor, β TGFBR3 281.3 87.5 3.2 0.001633 signal transduction;
receptor III signaling pathway
ataxin 2-like ATXN2L 920.9 288.4 3.2 0.000103 unknown
Full length insert cDNA YH77E09 --- 263.8 84.0 3.1 0.000034 unknown
actin binding LIM protein 1 ABLIM1 537.3 173.3 3.1 0.000096 cytoskeleton
organization and
biogenesis
aminopeptidase puromycin NPEPPS 996.0 323.1 3.1 0.000000 proteolysis and
sensitive peptidolysis
golgin-67 GOLGIN-67 343.8 112.1 3.1 0.000006 Golgi apparatus
amyloid beta precursor protein APPBP2 252.7 82.8 3.1 0.000021 intracellular
binding protein 2 protein transport
serine/threonine kinase 6 STK6 252.1 82.8 3.0 0.000732 protein
phosphorylation;
cell cycle; mitosis
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