Table 4 of
Cai, Mol Vis 2006;
12:1-14.Table 4 of
Cai, Mol Vis 2006;
12:1-14.
Table 4. Genes within adult human RPE (ahRPE) upregulated genes >three fold compared to ARPE19
Data were generated from Affymetrix U95Av2 DNA microarray analysis of four ahRPE and five ARPE19 samples. Numbers shown in ahRPE and ARPE19 columns are the mean values of DNA microarray chip densitometry scan signals. Numbers shown in ahRPE/ARPE19 column are fold-changes comparing ahRPE gene expression level with ARPE19. Numbers in p value column are from student t-test. Asterisk indicates genes within 2,500 most abundant gene list (data not shown).
ARPE19/
Probe ID Gene title Symbol ahRPE ARPE19 ahRPE p value Gene functions
----------- ---------------------- ---------- ------ ------ ------- -------- -----------------
36533_at* prostaglandin I2 PTGIS 1254.8 71.2 17.6 0.000023 electron
(prostacyclin) transport; lipid
synthase metabolism
41294_at* keratin 7 KRT7 4157.1 239.2 17.4 0.000250 cytoskeleton
organization and
biogenesis
34265_at* secretory granule, SGNE1 305.6 45.3 6.7 0.000000 protein folding;
neuroendocrine protein intracellular
1 (7B2 protein) protein transport
32434_at myristoylated MARCKS 328.3 50.8 6.5 0.000000 cell motility
alanine-rich protein
kinase C substrate
38957_at doublecortin and CaM DCAMKL1 260.0 43.4 6.0 0.001277 protein
kinase-like 1 phosphorylation;
endosome
transport
41505_r_at v-maf MAF 133.3 23.6 5.7 0.001446 regulation of
musculoaponeurotic transcription
fibrosarcoma oncogene
homolog
39927_at Rho GTPase activating ARHGAP5 120.4 21.4 5.6 0.000301 cell adhesion
protein 5
40367_at bone morphogenetic BMP2 245.6 49.9 4.9 0.000051 skeletal
protein 2 development;
cell-cell
signaling
40455_at* KIAA0830 protein KIAA0830 609.6 125.1 4.9 0.000021 nucleic acid
binding;
endonuclease
activity
865_at* ribosomal protein S6 RPS6KA3 936.4 194.0 4.8 0.000269 skeletal
kinase, 90 kDa, development;
polypeptide 3 protein
phosphorylation
40035_at* kallikrein 11 KLK11 1023.1 213.3 4.8 0.000000 proteolysis and
peptidolysis
40493_at* CD44 antigen CD44 2812.0 604.9 4.6 0.000027 cell adhesion;
cell-matrix
adhesion
33103_s_at adducin 3 (γ) ADD3 115.8 25.1 4.6 0.000006 calmodulin
binding
38634_at* retinol binding RBP1 1152.3 250.5 4.6 0.000012 vitamin A
protein 1, cellular metabolism;
transport
33236_at* retinoic acid receptor RARRES3 406.3 90.8 4.5 0.000080 growth regulatory
responder (tazarotene protein; tumor
induced) 3 suppressor
31720_s_at* fibronectin 1 FN1 1496.7 341.1 4.4 0.000050 cell adhesion;
cell migration
33849_at pre-B-cell colony PBEF1 150.5 34.6 4.4 0.003907 signal
enhancing factor 1 transduction;
cell
proliferation
regulation
38138_at* S100 calcium binding S100A11 3690.0 848.9 4.3 0.000001 negative
protein A11 regulation of
(calgizzarin) cell
proliferation
34642_at* tyrosine YWHAZ 2301.6 544.5 4.2 0.000003 protein domain
3-monooxygenase specific binding
activation protein
266_s_at CD24 antigen (small CD24 129.5 32.0 4.0 0.005621 immune response
cell lung carcinoma
cluster 4 antigen)
40227_at* discoidin, CUB and DCBLD2 1007.5 260.5 3.9 0.000037 cell adhesion;
LCCL domain containing wound healing
2
1456_s_at interferon, IFI16 118.2 31.1 3.8 0.000007 immune response;
γ-inducible cell
protein 16 proliferation
32533_s_at* vesicle-associated VAMP5 577.1 155.0 3.7 0.000002 myogenesis;
membrane protein 5 vesicle-mediated
(myobrevin) transport
40500_at NDRG family member 4 NDRG4 290.6 78.8 3.7 0.000398 response to
stress; cell
differentiation
1991_s_at* mitogen-activated MAPKAPK3 1195.9 329.0 3.6 0.000009 protein
protein phosphorylation;
kinase-activated response to
protein kinase 3 stress
35726_at* S100 calcium binding S100A2 1584.2 437.1 3.6 0.000071 calcium ion
protein A2 binding
36262_at* glucosamine GNS 1089.7 303.0 3.6 0.000969 glycosaminoglycan
(N-acetyl)-6-sulfatase catabolism;
(Sanfilippo disease metabolism
IIID)
33863_at* hypoxia upregulated 1 HYOU1 4796.3 1336.2 3.6 0.000001 protein folding;
response to
stress
672_at* serine (or cysteine) SERPINE1 2268.9 676.6 3.4 0.000211 blood coagulation
proteinase inhibitor
35769_at* G protein-coupled GPR56 1484.9 445.4 3.3 0.000580 neuropeptide
receptor 56 signaling pathway;
metabolism
37628_at* monoamine oxidase B MAOB 289.5 87.3 3.3 0.000175 electron
transport
37319_at* insulin-like growth IGFBP3 1438.0 437.2 3.3 0.008582 cell growth and
factor binding protein apoptosis
3 regulation
34886_at* radixin RDX 402.1 123.6 3.3 0.000024 cytoskeletal
anchoring
38500_at* CGI-109 protein CGI-109 611.8 190.3 3.2 0.000012 intracellular
protein transport
33339_g_at signal transducer and STAT1 111.9 35.0 3.2 0.000024 regulation of
activator of cell cycle;
transcription 1, caspase
91 kDa activation
39373_at* fatty acid desaturase FADS1 478.7 150.3 3.2 0.001098 fatty acid
1 biosynthesis;
cell-cell
signaling
37391_at* cathepsin L CTSL 3573.0 1126.1 3.2 0.000572 proteolysis and
peptidolysis
1034_at* tissue inhibitor of TIMP3 1293.7 412.0 3.1 0.000456 visual
metalloproteinase 3 perception;
induction of
apoptosis
37405_at* selenium binding SELENBP1 995.0 317.0 3.1 0.000836 selenium binding
protein 1
160020_at* matrix MMP14 2332.0 748.7 3.1 0.000168 proteolysis and
metalloproteinase 14 peptidolysis
(membrane-inserted)
35992_at* musculin (activated MSC 576.5 186.0 3.1 0.000157 regulation of
B-cell factor-1) transcription
31783_at* renin binding protein RENBP 321.7 103.8 3.1 0.000111 mannose
metabolism
40848_g_at flavoprotein MICAL2 263.6 85.4 3.1 0.000186 electron
oxidoreductase MICAL2 transport;
metabolism
33989_f_at* testis enhanced gene TEGT 3358.8 1092.8 3.1 0.000171 negative
transcript (BAX regulation of
inhibitor 1) apoptosis
40913_at* ATPase, Ca++ ATP2B4 734.8 239.6 3.1 0.000002 calcium ion
transporting, plasma transport;
membrane 4 metabolism
38837_at hypothetical protein DJ971N18.2 174.9 57.2 3.1 0.000004 electron
DJ971N18.2 transport
33372_at* RAB31, member RAS RAB31 830.0 271.3 3.1 0.000467 small GTPase
oncogene family mediated signal
transduction
2092_s_at secreted SPP1 93.7 30.7 3.1 0.000096 anti-apoptosis;
phosphoprotein 1 cell-matrix
adhesion
41739_s_at caldesmon 1 CALD1 224.9 73.8 3.0 0.000160 muscle
contraction;
muscle
development
40433_at* glucosamine GNS 575.3 191.0 3.0 0.000111 glycosaminoglycan
(N-acetyl)-6-sulfatase catabolism;
(Sanfilippo disease metabolism
IIID)
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