Table 4 of
Cai, Mol Vis 2006;
12:1-14.
Table 4. Genes within adult human RPE (ahRPE) upregulated genes >three fold compared to ARPE19
Data were generated from Affymetrix U95Av2 DNA microarray analysis of four ahRPE and five ARPE19 samples. Numbers shown in ahRPE and ARPE19 columns are the mean values of DNA microarray chip densitometry scan signals. Numbers shown in ahRPE/ARPE19 column are fold-changes comparing ahRPE gene expression level with ARPE19. Numbers in p value column are from student t-test. Asterisk indicates genes within 2,500 most abundant gene list (data not shown).
ARPE19/ Probe ID Gene title Symbol ahRPE ARPE19 ahRPE p value Gene functions ----------- ---------------------- ---------- ------ ------ ------- -------- ----------------- 36533_at* prostaglandin I2 PTGIS 1254.8 71.2 17.6 0.000023 electron (prostacyclin) transport; lipid synthase metabolism 41294_at* keratin 7 KRT7 4157.1 239.2 17.4 0.000250 cytoskeleton organization and biogenesis 34265_at* secretory granule, SGNE1 305.6 45.3 6.7 0.000000 protein folding; neuroendocrine protein intracellular 1 (7B2 protein) protein transport 32434_at myristoylated MARCKS 328.3 50.8 6.5 0.000000 cell motility alanine-rich protein kinase C substrate 38957_at doublecortin and CaM DCAMKL1 260.0 43.4 6.0 0.001277 protein kinase-like 1 phosphorylation; endosome transport 41505_r_at v-maf MAF 133.3 23.6 5.7 0.001446 regulation of musculoaponeurotic transcription fibrosarcoma oncogene homolog 39927_at Rho GTPase activating ARHGAP5 120.4 21.4 5.6 0.000301 cell adhesion protein 5 40367_at bone morphogenetic BMP2 245.6 49.9 4.9 0.000051 skeletal protein 2 development; cell-cell signaling 40455_at* KIAA0830 protein KIAA0830 609.6 125.1 4.9 0.000021 nucleic acid binding; endonuclease activity 865_at* ribosomal protein S6 RPS6KA3 936.4 194.0 4.8 0.000269 skeletal kinase, 90 kDa, development; polypeptide 3 protein phosphorylation 40035_at* kallikrein 11 KLK11 1023.1 213.3 4.8 0.000000 proteolysis and peptidolysis 40493_at* CD44 antigen CD44 2812.0 604.9 4.6 0.000027 cell adhesion; cell-matrix adhesion 33103_s_at adducin 3 (γ) ADD3 115.8 25.1 4.6 0.000006 calmodulin binding 38634_at* retinol binding RBP1 1152.3 250.5 4.6 0.000012 vitamin A protein 1, cellular metabolism; transport 33236_at* retinoic acid receptor RARRES3 406.3 90.8 4.5 0.000080 growth regulatory responder (tazarotene protein; tumor induced) 3 suppressor 31720_s_at* fibronectin 1 FN1 1496.7 341.1 4.4 0.000050 cell adhesion; cell migration 33849_at pre-B-cell colony PBEF1 150.5 34.6 4.4 0.003907 signal enhancing factor 1 transduction; cell proliferation regulation 38138_at* S100 calcium binding S100A11 3690.0 848.9 4.3 0.000001 negative protein A11 regulation of (calgizzarin) cell proliferation 34642_at* tyrosine YWHAZ 2301.6 544.5 4.2 0.000003 protein domain 3-monooxygenase specific binding activation protein 266_s_at CD24 antigen (small CD24 129.5 32.0 4.0 0.005621 immune response cell lung carcinoma cluster 4 antigen) 40227_at* discoidin, CUB and DCBLD2 1007.5 260.5 3.9 0.000037 cell adhesion; LCCL domain containing wound healing 2 1456_s_at interferon, IFI16 118.2 31.1 3.8 0.000007 immune response; γ-inducible cell protein 16 proliferation 32533_s_at* vesicle-associated VAMP5 577.1 155.0 3.7 0.000002 myogenesis; membrane protein 5 vesicle-mediated (myobrevin) transport 40500_at NDRG family member 4 NDRG4 290.6 78.8 3.7 0.000398 response to stress; cell differentiation 1991_s_at* mitogen-activated MAPKAPK3 1195.9 329.0 3.6 0.000009 protein protein phosphorylation; kinase-activated response to protein kinase 3 stress 35726_at* S100 calcium binding S100A2 1584.2 437.1 3.6 0.000071 calcium ion protein A2 binding 36262_at* glucosamine GNS 1089.7 303.0 3.6 0.000969 glycosaminoglycan (N-acetyl)-6-sulfatase catabolism; (Sanfilippo disease metabolism IIID) 33863_at* hypoxia upregulated 1 HYOU1 4796.3 1336.2 3.6 0.000001 protein folding; response to stress 672_at* serine (or cysteine) SERPINE1 2268.9 676.6 3.4 0.000211 blood coagulation proteinase inhibitor 35769_at* G protein-coupled GPR56 1484.9 445.4 3.3 0.000580 neuropeptide receptor 56 signaling pathway; metabolism 37628_at* monoamine oxidase B MAOB 289.5 87.3 3.3 0.000175 electron transport 37319_at* insulin-like growth IGFBP3 1438.0 437.2 3.3 0.008582 cell growth and factor binding protein apoptosis 3 regulation 34886_at* radixin RDX 402.1 123.6 3.3 0.000024 cytoskeletal anchoring 38500_at* CGI-109 protein CGI-109 611.8 190.3 3.2 0.000012 intracellular protein transport 33339_g_at signal transducer and STAT1 111.9 35.0 3.2 0.000024 regulation of activator of cell cycle; transcription 1, caspase 91 kDa activation 39373_at* fatty acid desaturase FADS1 478.7 150.3 3.2 0.001098 fatty acid 1 biosynthesis; cell-cell signaling 37391_at* cathepsin L CTSL 3573.0 1126.1 3.2 0.000572 proteolysis and peptidolysis 1034_at* tissue inhibitor of TIMP3 1293.7 412.0 3.1 0.000456 visual metalloproteinase 3 perception; induction of apoptosis 37405_at* selenium binding SELENBP1 995.0 317.0 3.1 0.000836 selenium binding protein 1 160020_at* matrix MMP14 2332.0 748.7 3.1 0.000168 proteolysis and metalloproteinase 14 peptidolysis (membrane-inserted) 35992_at* musculin (activated MSC 576.5 186.0 3.1 0.000157 regulation of B-cell factor-1) transcription 31783_at* renin binding protein RENBP 321.7 103.8 3.1 0.000111 mannose metabolism 40848_g_at flavoprotein MICAL2 263.6 85.4 3.1 0.000186 electron oxidoreductase MICAL2 transport; metabolism 33989_f_at* testis enhanced gene TEGT 3358.8 1092.8 3.1 0.000171 negative transcript (BAX regulation of inhibitor 1) apoptosis 40913_at* ATPase, Ca++ ATP2B4 734.8 239.6 3.1 0.000002 calcium ion transporting, plasma transport; membrane 4 metabolism 38837_at hypothetical protein DJ971N18.2 174.9 57.2 3.1 0.000004 electron DJ971N18.2 transport 33372_at* RAB31, member RAS RAB31 830.0 271.3 3.1 0.000467 small GTPase oncogene family mediated signal transduction 2092_s_at secreted SPP1 93.7 30.7 3.1 0.000096 anti-apoptosis; phosphoprotein 1 cell-matrix adhesion 41739_s_at caldesmon 1 CALD1 224.9 73.8 3.0 0.000160 muscle contraction; muscle development 40433_at* glucosamine GNS 575.3 191.0 3.0 0.000111 glycosaminoglycan (N-acetyl)-6-sulfatase catabolism; (Sanfilippo disease metabolism IIID) |