Table 2 of
Kirwan, Mol Vis 2005;
11:798-810.Table 2 of
Kirwan, Mol Vis 2005;
11:798-810.
Table 2. Ontology of stretch responsive genes
This table lists the ontological categories (and their member genes) as generated by the NIH DAVID version 1.0 software. The individual categories of ECM, cell proliferation, growth factor activity, cell surface receptor linked signal transduction, and coagulation are shown here as they are the categories to which the 9 validated genes belong. Of particular interest to our work was the ECM category, which showed that 30 ECM genes were differentially expressed in stretch and control (24 upregulated, 6 downregulated).
Affymetrix
probe ID Gene Fold SLR
----------- -------------------------------------------------------------- ---- ----
Extracellular matrix
216269_s_at elastin 8 3
201262_s_at biglycan 3.7 1.9
212937_s_at collagen, type VI, alpha 1 3 1.6
214535_s_at ADAMTS2 2.6 1.4
220287_at ADAMTS9 2.3 1.2
204724_s_at collagen, type IX, alpha 3 2.3 1.2
205200_at tetranectin (plasminogen binding protein) 2.3 1.2
205524_s_at cartilage linking protein 1 2 1
216866_s_at collagen, type XIV, alpha 1 2 1
207118_s_at matrix metalloproteinase 23B 2 1
211571_s_at versican (chondroitin sulfate proteoglycan 2) 1.9 0.9
201654_s_at perlecan (heparan sulfate proteoglycan 2) 1.9 0.9
213640_s_at lysyl oxidase 1.9 0.9
216339_s_at tenascin XB 1.9 0.9
201107_s_at thrombospondin 1 1.9 0.9
210628_x_at latent transforming growth factor beta binding protein 4 1.7 0.8
205713_s_at cartilage oligomeric matrix protein 1.7 0.7
211966_at collagen, type IV, alpha 2 1.7 0.7
209156_s_at collagen, type VI, alpha 2 1.7 0.7
204358_s_at fibronectin leucine rich transmembrane protein 2 1.7 0.7
208005_at netrin 1 1.7 0.7
220705_s_at ADAMTS7 1.5 0.6
220677_s_at ADAMTS8 1.5 0.6
221900_at collagen, type VIII, alpha 2 1.5 0.6
207835_at fibulin 1 -1.5 -0.6
202007_at nidogen (enactin) -1.5 -0.6
212667_at secreted protein, acidic, cysteine-rich (osteonectin) -1.5 -0.6
201843_s_at EGF-containing fibulin-like extracellular matrix protein 1 -1.7 -0.8
203881_s_at dystrophin -2 -1
209758_s_at Microfibril-associated glycoprotein-2 -2 -1
Cell proliferation
203729_at epithelial membrane protein 3 3.5 1.8
200973_s_at transmembrane 4 superfamily member 8 3 1.6
214667_s_at tumor protein p53 inducible protein 11 2.3 1.2
209468_at low density lipoprotein receptor-related protein 5 2 1
211289_x_at cell division cycle 2-like 1 (PITSLRE proteins) 2 1
208711_s_at cyclin D1 (PRAD1: parathyroid adenomatosis 1) 1.9 0.9
203085_s_at transforming growth factor, beta 1 1.7 0.8
209908_s_at transforming growth factor, beta 2 1.7 0.8
201111_at CSE1 chromosome segregation 1-like (yeast) 1.6 0.7
201419_at BRCA1 associated protein-1 1.6 0.7
213977_s_at CDKN1A interacting zinc finger protein 1 1.6 0.7
202253_s_at dynamin 2 1.5 0.6
210513_s_at vascular endothelial growth factor 1.5 0.6
219708_at 5',3'-nucleotidase, mitochondrial 1.5 0.6
201641_at bone marrow stromal cell antigen 2 -1.5 -0.6
204998_s_at activating transcription factor 5 -1.5 -0.6
222243_s_at transducer of ERBB2, 2 -1.5 -0.6
206341_at interleukin 2 receptor, alpha -1.6 -0.7
218386_x_at ubiquitin specific protease 16 -1.6 -0.7
211297_s_at cyclin-dependent kinase 7 -1.7 -0.8
205207_at interleukin 6 (interferon, beta 2) -1.9 -0.9
207358_x_at microtubule-actin crosslinking factor 1 -1.9 -0.9
219049_at chondroitin beta1,4 N-acetylgalactosaminyltransferase -1.9 -0.9
202214_s_at cullin 4B -2 -1
202934_at hexokinase 2 -2 -1
Growth factor activity
209590_at bone morphogenetic protein 7 (osteogenic protein 1) 1.6 0.7
206814_at nerve growth factor, beta polypeptide 1.5 0.6
207595_s_at bone morphogenetic protein 1 1.5 0.6
221577_x_at growth differentiation factor 15 1.5 0.6
207865_s_at bone morphogenetic protein 8b (osteogenic protein 2) -1.5 -0.6
209961_s_at hepatocyte growth factor (hepapoietin A; scatter factor) -1.5 -0.6
206382_s_at brain-derived neurotrophic factor -1.6 -0.7
221404_at interleukin 1 family, member 6 (epsilon) -1.7 -0.8
210997_at hepatocyte growth factor (hepapoietin A; scatter factor) -2.6 -1.4
Cell surface receptor linked signal transduction
208677_s_at EMMPRIN/basigin (OK blood group) 2.5 1.3
213746_s_at filamin A, alpha (actin binding protein 280) 2.5 1.3
208703_s_at amyloid beta (A4) precursor-like protein 2 2.1 1.1
206534_at glutamate receptor, ionotropic, N-methyl D-aspartate 2A 2 1
210594_x_at myelin protein zero-like 1 2 1
208463_at gamma-aminobutyric acid (GABA) A receptor, alpha 4 1.9 0.9
212196_at interleukin 6 signal transducer (gp130, oncostatin M receptor) 1.9 0.9
207556_s_at diacylglycerol kinase, zeta 104 kDa 1.7 0.8
211590_x_at thromboxane A2 receptor 1.7 0.8
203882_at interferon-stimulated transcription factor 3, gamma 48 kDa 1.6 0.7
204379_s_at fibroblast growth factor receptor 3 1.6 0.7
205357_s_at angiotensin II receptor, type 1 1.5 0.6
205977_s_at EphA1 1.5 0.6
210651_s_at EphB2 1.5 0.6
214391_x_at prostaglandin E receptor 1 (subtype EP1), 42 kDa 1.5 0.6
220005_at G protein-coupled receptor 86 1.5 0.6
200653_s_at calmodulin 1 (phosphorylase kinase, delta) -1.5 -0.6
200745_s_at guanine nucleotide binding protein, beta polypeptide 1 -1.5 -0.6
204597_x_at stanniocalcin 1 -1.5 -0.6
216837_at EphA5 -1.5 -0.6
220336_s_at glycoprotein VI (platelet) -1.5 -0.6
204595_s_at stanniocalcin 1 -1.6 -0.7
209071_s_at regulator of G-protein signalling 5 -1.6 -0.7
216222_s_at myosin X -1.6 -0.7
219032_x_at opsin 3 (encephalopsin, panopsin) -1.6 -0.7
205168_at discoidin domain receptor family, member 2 -1.7 -0.8
221299_at super conserved receptor expressed in brain 3 -1.7 -0.8
202886_s_at protein phosphatase 2, regulatory subunit A, beta isoform -2 -1
214184_at neuropeptide FF-amide peptide precursor -2 -1
Coagulation
201107_s_at thrombospondin 1 1.9 0.9
209676_at tissue factor pathway inhibitor 1.5 0.6
210049_at serine proteinase inhibitor, clade C, member 1 1.5 0.6
211668_s_at plasminogen activator, urokinase 1.5 0.6
200986_at serine proteinase inhibitor, clade G, member 1 -1.5 -0.6
207808_s_at protein S (alpha) -1.5 -0.6
220336_s_at glycoprotein VI (platelet) -1.5 -0.6
213380_x_at macrophage stimulating 1 -1.9 -0.9
201860_s_at plasminogen activator, tissue -2 -1
203887_s_at thrombomodulin -3 -1.6
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