Figure 5 of
Seigel, Mol Vis 2005;
Figure 5. Subpopulations in human RB tissues immunoreactive to stem cell markers
We examined immunoreactivities of stem cell markers ABCG2 and ALDH1 in archival human retinoblastoma specimens. The chemoresistance marker ABCG2 was seen in areas of RB tumor (A) and sporadically within the retina itself (B). ALDH1 (Aldehyde dehydrogenase-1) immunoreactive human RB tumor cells are shown in (C). Immunoreactivity for both ABCG2 and ALDH1 in human tumors suggest the presence of cells that have a stem cell phenotype. Scale bars represent 10 μm.