Table 4 of
Fan, Mol Vis 2005;
**11**:625-631.

Table 4. Analysis of gene-gene interactions using common polymorphisms

Logistic regression analysis was used to test for interaction between polymorphisms. A stratified analysis (Breslow-Day tests for homogeneity of the odds ratios) was used to verify the significant interactions found in logistic regression analysis. The table shows p values for these tests.

HTG patients (n=294) compared to control subjects (n=281) Significant interactions Logistic Stratified between polymorphisms regression analysis ------------------------------------ ---------- ---------- T353I (MYOC) and IVS15+10G>A (OPTN) 0.030 0.016 IVS5+38T>G (OPTN) and -491A>T (APOE) 0.042 0.033 |

NTG patients (n=106) compared to control subjects (n=281) Significant interactions Logistic Stratified between polymorphisms regression analysis ------------------------------------ ---------- ---------- R545Q (OPTN) and ε2/ε3/ε4 (APOE) 0.019 0.003 -83G>A (MYOC) and ε2/ε3/ε4 (APOE) 0.019 0.011 IVS2+35A>G (MYOC) and -219T>G (APOE) 0.037 0.036 |

Fan, Mol Vis 2005;

©2005 Molecular Vision <http://www.molvis.org/molvis/>

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