Table 4 of
Fan, Mol Vis 2005;
11:625-631.Table 4 of
Fan, Mol Vis 2005;
11:625-631.
Table 4. Analysis of gene-gene interactions using common polymorphisms
Logistic regression analysis was used to test for interaction between polymorphisms. A stratified analysis (Breslow-Day tests for homogeneity of the odds ratios) was used to verify the significant interactions found in logistic regression analysis. The table shows p values for these tests.
HTG patients (n=294) compared to control subjects (n=281)
Significant interactions Logistic Stratified
between polymorphisms regression analysis
------------------------------------ ---------- ----------
T353I (MYOC) and IVS15+10G>A (OPTN) 0.030 0.016
IVS5+38T>G (OPTN) and -491A>T (APOE) 0.042 0.033
|
NTG patients (n=106) compared to control subjects (n=281)
Significant interactions Logistic Stratified
between polymorphisms regression analysis
------------------------------------ ---------- ----------
R545Q (OPTN) and ε2/ε3/ε4 (APOE) 0.019 0.003
-83G>A (MYOC) and ε2/ε3/ε4 (APOE) 0.019 0.011
IVS2+35A>G (MYOC) and -219T>G (APOE) 0.037 0.036
|