Table 2 of
Floyd, Mol Vis 2005;
11:524-530.
Table 2. Incidence and severity of neovascularization
In oxygen-induced retinopathy (OIR) rats, the incidence of neovascularization (NV) was higher in Brown Norway (BN) than Sprague Dawley (SD) rats. NV was more severe in BN rats. The incidence of NV in acidosis-induced retinopathy (AIR) rats was similar in BN and SD rats. Any difference between animal survival and retinas analyzed was due to a number of retinas deemed ungradable by the masked examiner (e.g., 20 OIR SD rats survived and 19 OIR SD retinas were analyzed). The highest dose tolerated in AIR was 15 mmol/kg twice daily for the first day of gavage and then 10 mmol/kg twice daily thereafter.
Severity of NV in clock hours Conditions ---------------- and strain Animal survival Incidence of NV Median Range ------------ --------------- --------------- ------ ------- OIR BN 20/20 (100%) 20/20 (100%) 7 1 to 10 OIR SD 20/20 (100%) 1/19 (5%) 0 0 to 1 AIR BN 33/40 (83%) 1/23 (4%) 0 0 to 1 (10 mmol/kg) AIR SD 36/40 (90%) 0/33 (0%) NA NA (10 mmol/kg) AIR BN 11/20 (55%) 2/11 (18%) 1.5 0 to 2 (15 mmol/kg) AIR SD 17/20 (85%) 0/17 (0%) 0 NA (15 mmol/kg) Controls 60/60 (100%) 1/57 (2%) 0 0 to 1 (OIR + AIR) |