Table 2 of Floyd, Mol Vis 2005; 11:524-530.


Table 2. Incidence and severity of neovascularization

In oxygen-induced retinopathy (OIR) rats, the incidence of neovascularization (NV) was higher in Brown Norway (BN) than Sprague Dawley (SD) rats. NV was more severe in BN rats. The incidence of NV in acidosis-induced retinopathy (AIR) rats was similar in BN and SD rats. Any difference between animal survival and retinas analyzed was due to a number of retinas deemed ungradable by the masked examiner (e.g., 20 OIR SD rats survived and 19 OIR SD retinas were analyzed). The highest dose tolerated in AIR was 15 mmol/kg twice daily for the first day of gavage and then 10 mmol/kg twice daily thereafter.

                                                    Severity of NV
                                                    in clock hours
 Conditions                                        ----------------
 and strain    Animal survival   Incidence of NV   Median    Range
------------   ---------------   ---------------   ------   -------
OIR BN          20/20 (100%)      20/20 (100%)      7       1 to 10
OIR SD          20/20 (100%)       1/19   (5%)      0       0 to  1

AIR BN          33/40  (83%)       1/23   (4%)      0       0 to  1
(10 mmol/kg)
AIR SD          36/40  (90%)       0/33   (0%)      NA      NA
(10 mmol/kg)

AIR BN          11/20  (55%)       2/11  (18%)      1.5     0 to  2
(15 mmol/kg)
AIR SD          17/20  (85%)       0/17   (0%)      0       NA
(15 mmol/kg)

Controls        60/60 (100%)       1/57   (2%)      0       0 to  1
(OIR + AIR)

Floyd, Mol Vis 2005; 11:524-530 <http://www.molvis.org/molvis/v11/a61/>
©2005 Molecular Vision <http://www.molvis.org/molvis/>
ISSN 1090-0535