Figure 4. CRYGD gene partial nucleotidic sequence

A: Sequence electropherogram showing a G to A transition at nucleotide position 441 (arrow) in CRYGD exon 2. The substitution of histidine for arginine at residue 58 of CRYGD protein (Arg-58 to His) is expected and found in the five affected individuals studied. B: A electropherogram showing this mutation was not observed in DNA from unaffected family members or from 50 control alleles.