Table 3 of
Ishikawa, Mol Vis 2005;
11:431-437.Table 3 of
Ishikawa, Mol Vis 2005;
11:431-437.
Table 3. Genotype and allele frequencies
The distributions in controls and OAG patients were consistent with the Hardy-Weinberg equilibrium. Genotype distributions showed no significant differences between OAG patients and control subjects adjusted by age. Data shown are counts with percentages in parentheses. Analysis of the genotype used both a χ2 test ("Chi square") and logistic regression analysis that allowed adjustment for age ("Logistic p value"); analysis of the allele frequency used a χ2 test only.
Chi Chi
square Logistic square
Polymorphism Sample Genotype frequency p value p value Allele frequency p value
------------ ------- ----------------------- ------- -------- ----------------------- -------
TT TG+GG T G
---------- ---------- ---------- ----------
EDN1/T-1370G Control 133 (59.4) 91 (40.6) 350 (78.1) 98 (21.9)
(n=224)
OAG 273 (64.1) 153 (35.9) 0.239 0.561 675 (79.2) 177 (20.8) 0.644
(n=426)
del/ins+
del/del ins/ins del ins
---------- ---------- ---------- ----------
EDN1/+138/ex1 Control 146 (65.2) 78 (34.8) 364 (81.3) 84 (18.8)
del/ins (n=224)
OAG 316 (74.2) 110 (25.8) 0.016 0.206 734 (86.2) 118 (13.8) 0.020
(n=426)
KK KN+NN K N
---------- ---------- ---------- ----------
EDN1/K198N Control 98 (43.8) 126 (56.3) 295 (65.8) 153 (34.2)
(n=224)
OAG 226 (53.2) 199 (46.8) 0.022 0.368 609 (71.6) 241 (28.4) 0.031
(n=425)
GG GA+AA G A
---------- ---------- ---------- ----------
EDNRA/G-231A Control 62 (27.7) 162 (72.3) 244 (54.5) 204 (45.5)
(n=224)
OAG 118 (27.8) 307 (72.2) 0.981 0.777 455 (53.5) 395 (46.5) 0.748
(n=425)
TT TC+CC T C
---------- ---------- ---------- ----------
EDNRA/H323H Control 122 (54.5) 102 (45.5) 327 (73.0) 121 (27.0)
(n=224)
OAG 228 (53.5) 198 (46.5) 0.819 0.539 626 (73.5) 226 (26.5) 0.852
(n=426)
CC CG+GG C G
---------- ---------- ---------- ----------
EDNRA/C+70G Control 61 (27.2) 163 (72.8) 229 (51.1) 219 (48.9)
(n=224)
OAG 128 (30.0) 298 (70.0) 0.453 0.302 462 (54.2) 390 (45.8) 0.286
(n=426)
CC CT+TT C T
---------- ---------- ---------- ----------
EDNRA/C+1222T Control 137 (61.2) 87 (38.8) 347 (77.5) 101 (22.5)
(n=224)
OAG 224 (52.6) 202 (47.4) 0.036 0.122 620 (72.8) 232 (27.2) 0.066
(n=426)
AA AG+GG A G
---------- ---------- ---------- ----------
EDNRB/L277L Control 77 (34.4) 147 (65.6) 254 (56.7) 194 (43.3)
(n=224)
OAG 118 (27.8) 307 (72.2) 0.081 0.096 443 (52.1) 407 (47.9) 0.116
(n=425)
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