Table 2 of
Hollborn, Mol Vis 2005;
11:397-413.Table 2 of
Hollborn, Mol Vis 2005;
11:397-413.
Table 2. Genes detectable in PVR retinas
Genes that were expressed in retinas from patients with PVR but were classified as absent in postmortem control retinas. Two retinas of patients with PVR were investigated, and the magnitude of change for a specific gene was estimated by using the mean value of 7 control postmortem retinas. Each mean value from the control retinas was non-zero, but was so low that it could not be classified as expressed in the control retinas.
Fold change in
expression
Accession -------------------
number Gene description Retina 1 Retina 2
--------- --------------------------------------------- -------- --------
Cytosolic structural proteins
AL050396 filamin A, a (actin binding protein 8.16 22.6
280-FLNA)
M19267 Tropomyosin 1 a (TPM1) 4.47 5.08
Translation protein
Z23090 heat shock 27 kDa protein 1 (HSPB1) 9.95 5.40
Signaling proteins
M12174 ras-related rho (ARHB) 39.29 131.64
U47931 G-protein β-3 subunit (GNB3) 27.28 48.89
X93510 LIM domain protein (RIL) 27.52 20.62
J00277 c-Ha-ras1proto-oncogene (HRAS) 14.71 11.62
X69550 Rho GDP-dissociation inhibitor 1 (ARHGDIA) 12.09 13.00
U66676 calcium/calmodulin dependent protein kinase 6.84 6.59
kinase 2, (CAMKK2)
W28790 pleckstrin homology domain containing, 6.64 6.24
family B (evectins) member 1 (PLEKHB1)
U42390 triple functional domain (TRIO) 6.47 6.24
AI952982 growth arrest and DNA damage inducible, g 4.53 4.71
(GADD45G)
U59423 Smad1 5.87 4.52
Nuclear and cell cycle related proteins
J04076 early growth response 2 (EGR2) 47.52 96.94
U79273 eukaryotic translation initiation factor 4A 40.15 31.00
(EIF41A)
U21551 ECA39 25.73 44.61
L49169 F0SB 36.14 33.33
Z50194 PQ rich protein (PHLDA1) 20.79 34.38
M99587 H6 homeodomain protein (HMX1) 16.85 14.73
X78992 ERF-2 17.08 14.48
AF043244 apoptosis repressor (NOL3) 15.49 14.78
X92857 NFI/CAAT binding transcription factor 5 11.66 16.12
(NFIC)
X56687 upstream binding transcription factor, RNA 13.10 10.48
polymerase I (UBTF)
L13740 TR3 orphan receptor 12.39 7.59
D42040 bromodomain containing 2 (BRD2) 10.11 8.84
X80200 TNF receptor associated factor 4 (TRAF4) 8.26 7.57
U03106 wild type p53 activated fragment-1 (WAF1) 8.19 7.55
X63741 pilot 5.89 8.37
U90268 Krit1 6.78 5.47
AB002328 calcineurin binding protein 1 (CABIN1) 5.87 4.91
M64349 cyclin D1 (CCND1) 4.68 4.37
AJ131186 nuclear matrix protein (NMP200) 3.71 4.99
Mitochondrial protein
U08997 glutamate dehydrogenase 2 (GLUD2) 4.02 4.49
Extracellular matrix proteins
M10905 cellular fibronectin (FN1) 217.73 93.70
D11139 tissue inhibitor of metalloproteinase 1 49.61 14.28
(TIMP1)
M26326 keratin 18 31.77 13.86
X04412 gelsolin (GSN) 7.22 9.99
U14394 tissue inhibitor of metalloproteinase-3 7.00 7.56
(TIMP3)
Secretory proteins
M62402 insulin-like growth factor binding protein 6 49.26 41.68
(IGFBP6)
X16302 insulin-like growth factor binding protein 2 12.46 23.79
(IGFBP2)
D90144 LD78 a precursor 8.78 5.64
M60278 heparin binding EGF-like growth factor 6.97 4.89
(HB-EGF)
X16323 hepatocyte growth factor (HGF) 6.41 6.79
U43842 bone morphogenetic protein 4 (BMP4) 5.20 5.39
Y12661 strong similarity to neuroendocrine 4.40 5.63
specific protein VGF
Membrane proteins
U27185 retinoic acid receptor responder (RARRES1) 63.35 101.70
AB020701 sorbin and SH3 domain containing 1 (SORBS1) 11.23 14.67
AB002438 sema domain, transmembrane domain (TM), and 8.71 5.98
cytoplasmic domain, (semaphorin) 6A (SEMA6A)
D83492 Eph-family protein (EPHB6) 5.26 5.54
AB007953 KIAA0484; cytokine receptor-like factor 2 4.65 5.28
Miscellaneous
AA165701 chondroitin polymerizing factor (CHPF) 18.36 28.93
J00153 α globin 14.48 10.81
U60644 HU-K4 (phospholipase D3 - PLD3) 7.52 8.03
D84239 IgG Fc binding protein 6.93 6.88
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