Table 1 of
Danciger, Mol Vis 2005;
11:374-379.Table 1 of
Danciger, Mol Vis 2005;
11:374-379.
Table 1. Quantitative trait loci
Table shows the LRS, LOD score, percent effect, percent genetic effect, inheritance pattern, and which allele is protective against constant light-induced retinal damage for the quantitative trait loci (QTL) detected in this constant light-induced retinal degeneration intercross study between NZW/LacJ and C57BL/6J-c2J. In the Significance (Sig) column, HS represents highly significant, S represents significant, and Sugg represents suggestive, NS represents not significant. CentiMorgan (cM) positions are the distances from the centromere taken from linkage maps at the MGI web site (JAX). Megabase (Mb) positions were determined from the MGSCv3 sequence database and rounded to the nearest 0.1 million bases from the centromere. The "-" percentage genetic effect score indicates an NZW protective allele; all other percentage genetic effect scores indicate B6al protective alleles.
% effect
Markers (% total Best fitting
at peak cM from Mb from LOD genetic inheritance
Sig of QTL centromere centromere LRS score effect) model
-------- --------- ---------- ---------- ---- ----- --------- ------------
controls - - - 82.4 17.91 65 (100) -
HS D1Mit132 43 77.6 24.0 5.22 -11 (17) recessive
D1Mit308 62 104.8
S D1Mit426 101 180.6 15.0 3.26 7 (11) recessive
D1Mit155 112 193.7
Sugg D14Mit68 39 64.2 10.4 2.26 5 (8) additive
D14Mit75 54 -
Sugg D16Mit107 3 5.1 9.8 2.13 5 (8) additive
D16Mit60 23 32.5
Sugg D10Mit49 2 4.1 9.1 1.98 4 (6) dominant
D10Mit126 21 26.8
Sugg D13Mit213 59 99.8 8.9 1.93 -4 (6) recessive
D13Mit78 75 113.2
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