Figure 9 of
Liu, Mol Vis 2005;
11:321-327.Figure 9 of
Liu, Mol Vis 2005;
11:321-327.
Figure 9. Sequence alignment and β-strand distribution of βB2- and γB-crystallin
This alignment shows the similarity between βB2- and γB-crystallin in the distribution of β-strands. The blue sequences indicate β-strand and the red sequences indicate α-helix. The sequence numbering is based on the sequence of the wild type βB2-crystallin. The distribution of β-strands is taken from Bax et al. [5] for βB2-crystallin and Kumaraswamy et al. [8] for γB-crystallin.
15 25 35 45 55
βB2 LNPKIIIFEQ ENFQGHSHEL NGPCPNLKET GVEKAGSVLV QAGPWVGYEQ
KI +E FQGH +E + CPNL+ + S+ V +G W+ YE+
γB MGKITFYED RGFQGHCYEC SSDCPNLQPY -FSRCNSIRV DSGCWMLYER
β1 β2 β3 β4
65 75 85 95 105
βB2 ANCKGEQFVF EKGEYPRWDS WTSSRRTDSL SSLRPIKVDS QEHKITLYEN
N +G Q+ +G+YP P + +I YE
γB PNYQGHQYFL RRGDYPDYQQ WMGFNDSIRS CRLIPQHTGT FRMRI--YER
β5 β6 β7 β8
115 125 135 145 155
βB2 PNFTGKKMEV IDDDVPSFHA HGYQEKVSSV RVQSGTWVGY QYPGYRGLQY
+F G+ E+ DD PS + +V S+ V G+WV Y + P YRG QY
γB DDFRGQMSEI TDD-CPSLQD RFHLTEVHSL NVLEGSWVLY EMPSYRGRQY
β9 α1 β10 β11 β12
165 175 185 195
βB2 LLEKGDYKDS GDFGAPQPQV QSVRRIRDMQ W
LL G+Y+ D+GA + +V S+RR+ D
γB LLRPGEYRRY LDWGAMNAKV GSLRRVMDFY
β13 α2 β14
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