Figure 5. Transgenic eyes have vascular membranes in the vitreous

Hematoxylin and eosin stained images are shown of a non-transgenic eye (A), and LIF transgenic eye (B) at P21. In the non-transgenic eye, the hyaloid vascular system has regressed. However, blood vessels are evident in the vitreous in the transgenic eyes (B, arrow). Retinal detachment from the RPE and subsequent attachment to the lens was often observed in transgenic animals (C). In such eyes, the lens and retina are separated by blood vessels and a fibrous matrix (D, arrow).