Figure 4 of
van den Hurk, Mol Vis 2005;
11:263-273.Figure 4 of
van den Hurk, Mol Vis 2005;
11:263-273.
Figure 4. Alignment of cbEGF-like domains
Alignment of the cbEGF-like domains of Drosophila (Dm) Crumbs (CRB; M33753), human (Hs) CRB1 (AY043325), and human (Hs) CRB2 (AY720432). Amino acid substitutions identified in the cbEGF-like domains of CRB2 in RP and LCA patients are indicated under the alignment. Identical amino acids are indicated in red and conserved residues in blue. Components of each line: organism, protein name, number of EGF-like domain, N-terminal amino acid position of the EGF-like domain, amino acid sequence of the EGF-like domain.
Dm CRB EGF4 386 DTDECASQ--PCQNNGSCID--------------------------RINGFSCDCSGT-----GYTGAFCQT
Dm CRB EGF5 425 NVDECDKN--PCLNGGRCFDTYG--------------------------WYTCQCLDG------WGGEICDR
Dm CRB EGF11 646 DVDECTLHPKIC-GNGICKNEKG--------------------------SYKCYCTPG------FTGVHCDS
Dm CRB EGF12 685 DVDECLSF--PCLNGATCHNKIN--------------------------AYECVCQPG------YEGENCEV
Dm CRB EGF13 723 DIDECGSN--PCSNGSTCIDRIN--------------------------NFTCNCIPG------MTGRICDI
Dm CRB EGF14 761 DIDDCVGD--PCLNGGQCID--------------------------QLGGFRCDCSGT-----GYEGENCEL
Dm CRB EGF15 800 NIDECLSN--PCTNGAKCLDRVK--------------------------DYFCDCHNG------YKGKNCEQ
Dm CRB EGF16 838 DINECESN--PCQYNGNCLERSNITLYQMSRITDLPKVFSQPFSFENASGYECVCVP------GIIGKNCEI
Dm CRB EGF17 902 NINECDSN--PCSKHGNCN----------------D----------GIGTYTCECEP------GFEGTHCEI
Dm CRB EGF18 940 NIDECDRYN-PCQRG-TCYDQID--------------------------DYDCDCDAN------YGGKNCSV
Dm CRB EGF24 1794 DIDEC-LNT-ECLNNGTCINQVA--------------------------AFFCQCQPG------FEGQHCEQ
Dm CRB EGF25 1832 NIDECADQ--PCHNGGNCTDLIA--------------------------SYVCDCPED------YMGPQCDV
Dm CRB EGF28 1950 DINECESN--PCQNGGQCKD---------------L-----------VGRYECDCQGT-----GFEGIRCEN
Dm CRB EGF29 1989 DIDECNMEGDYCGGLGRCFNKPG--------------------------SFQCICQKP------YCGAYCNF
Hs CRB1 EGF4 148 DHDECASS--PCQNGAVCQDGID--------------------------GYSCFCVP------GYQGRHCDL
Hs CRB1 EGF5 186 EVDECASD--PCKNEATCLNEIG--------------------------RYTCICPHN------YSGVNCEL
Hs CRB1 EGF6 224 EIDECWSQ--PCLNGATCQDALG--------------------------AYFCDCAP------GFLGDHCEL
Hs CRB1 EGF7 262 NTDECASQ--PCLHGGLCVD--------------------------GENRYSCNCTGS-----GFTGTHCET
Hs CRB1 EGF9 339 DLNECNSN--PCQSNGECVELS--SEKQYGRITGLP----SSFSYHEASGYVCICQP------GFTGIHCEE
Hs CRB1 EGF10 397 DVNECSSN--PCQNGGTCENLPG--------------------------NYTCHCPFDNLSRTFYGGRDCSD
Hs CRB1 EGF16 1177 NIDECFSN--PCIHGN-CSDRVA--------------------------AYHCTCEPG------YTGVNCEV
Hs CRB1 EGF17 1214 DIDNCQSH--QCANGATCISHTN--------------------------GYSCLCFGN------FTGKFCRQ
Hs CRB1 EGF19 1297 DIDECASD--PCVNGGLCQDLLN--------------------------KFQCLCDV------AFAGERCEV
Hs CRB2 EGF3 108 DIDECASR--PCHHGATCRNLAD--------------------------RYECHCPLG------YAGVTCEM
Hs CRB2 EGF4 146 EVDECASA--PCLHGGSCLDGVG--------------------------SFRCVCAP------GYGGTRCQL
Hs CRB2 EGF5 184 DLDECQSQ--PCAHGGTCHD--------------------------LVNGFRCDCAGT-----GYEGTHCER
Hs CRB2 EGF6 223 EVLECASA--PCEHNASCLEGLG--------------------------SFRCLCWP------GYSGELCEV
Hs CRB2 EGF7 261 DEDECASS--PCQHGGRCLQRSDPALYGGVQAAFPG-----AFSFRHAAGFLCHCPP------GFEGADCGV
Hs CRB2 EGF8 320 EVDECASR--PCLNGGHCQDLPN--------------------------GFQCHCPD------GYAGPTCEE
Hs CRB2 EGF9 358 DVDECLSD--PCLHGGTCSDTVA--------------------------GYICRCPET------WGGRDCSV
| | | | |
E187 | G159A A351T |
P116L M145T
|