Figure 4. Inhibition of corneal angiogenesis by topical application of vasostatin (VS)

A: Representative photographs of basic fibroblast growth factor (bFGF) implanted corneas after topical application of control eye drop (left panel) and VS containing eye drop (100 ng/ml; right panel) for 7 days. The asterisk represents the place of hydron pellet implantation. B: The effect of topical VS application on bFGF induced corneal angiogenesis. After implantation of bFGF pellets, the mean vessel length (left panel) and vascularized area (right panel) in rat corneas treated with phosphate buffered saline eye drops or VS eye drops were measured on days 3, 5, and 7. Asterisks indicate statistical significance (single asterisk for p<0.05, double asterisk for p<0.01). Bars represent the means and the error bars represent the SEM.