Table 1. Pattern of immunolabeling in retinas of mammalian species with the anti-chick CNTFRα antibody

Intensity of labeling was graded as intense (+++), moderate (++), weak (+), or absent (0); RPE staining was not determined (ND) in some species. In mouse RPE, nonspecific labeling could also be observed on negative control sections. Labeling was intense in PD3 and PD6 rats. Data for "Dog" are taken from from a previous study [18]. For dog and human outer nuclear layer (ONL), labeling was limited to cone soma, axon, and pedicle. For cat ONL, labeling was limited to cone soma and some cone axons. For sheep and pig ONL, labeling was limited to cone soma. Retinal pigment epithelium (RPE) pigmentation and autofluorescence precluded assessing the presence of specific labeling in pig, monkey, and human. In pig inner segments (IS), labeling was limited to the inner portion of the IS.

Retinal
 layer    Mouse   Rat   Dog   Cat   Sheep   Pig   Monkey   Human
-------   -----   ---   ---   ---   -----   ---   ------   -----
  RPE      ND     0     +++   +++    +++    ND     ND       ND
  OS       0      0     0     0      +      0      0        0
  IS       0      0     +++   +++    +++    ++     +++      +++
  ONL      0      0     +++   ++     +      +++    ++       +++
  OPL      ++     ++    +++   ++     ++     +++    +++      +++
  INL      +++    +++   +++   +++    +++    +++    +++      ++
  IPL      ++     ++    +     ++     +      +      +        +
  GCL      +++    +++   +++   +++    +++    +++    +++      +++
  NFL      +++    ++    +++   +++    ++     +++    +++      +++