Figure 1 of
Shimauchi-Matsukawa, Mol Vis 2005;
11:1220-1228.Figure 1 of
Shimauchi-Matsukawa, Mol Vis 2005;
11:1220-1228.
Figure 1. The deduced amino acid sequence of carp GRK1
Identical amino acids are shown by red letters. Blue line shows the catalytic domain of GRK1, turquoise shows the Gly loop, "GXGXXGX", which is thought to be involved in the ATP-binding, and green indicates the lipid-modification site (the "CaaX" motif) [4].
Bovine GRK1 1 MDFGSLETVVANSAFIAARGSFDASSGPAS-RDRKYLARLKLPPLSKCEALRESLDLGFEGMCLEQPIGKRLFQQFLRTHEQHGPALQLWKDIEDYDTAD 99
Fugu GRK1A-1 1 MDIGGLTTVVANSAYISARGSLDGTANPAANRDQKYHSRLKLPHITVCESLRETLDLGFQTVCVEQPIGKRLFQEFLNSKSEYKGSGHLWKDVEEYNMAE 100
Carp GRK1A-1a 1 MDIGGLTTVVANSAYISARGSFDGTANPAANRDKKYHAKLKLPHITVCEGLRETLDLQFKSICVEQPIGKRLFQEFLETTNEYKGPCRLWKDIETYDTAE 100
Carp GRK1A-1b 1 MDIGGLTTVVANSAYISARGSFDGTANPAANRDKKYHAKLKLPHITVCEDLRETLDLQFKSICVEQPIGKRLFQEYLEITNEYKGPCRLWKDIEAYDTAE 100
Fugu GRK1A-2 488 MDIGGLTTVVANSAYINARGSIDGT-NSAAARDKKFHSRLKLPHITVCEGLRDTLDLSFDTVCVEQPIGKRLFREFLDANKEYHGSCRLWRDIESYDLAE 586
Fugu GRK1B 1 MDIGGLETVVANSAYVSARGSMDGA-AAATMRDKKMRARLNLPHIRDCQAMKSTIDTTFDSICIKQPIGKRLFQQFLNSDAAHKNVGELWKDIEDYNVCQ 99
Carp GRK1Ba 1 MDIGGLETVVANSAYVSARGSIDSA-AAATMRDKKYRTKLNLPHIRQCEHMKTTVDSSFDSMCVRQPIGKRLFQQYIESETAHKNSVDLWKDIEDYNVAQ 99
Carp GRK1Bb 0 ---------------------------------------------------------------------------------------------------- 0
-----------
Bovine GRK1 100 DALRPQKAQALRAAYLEPQAQLFCSFLDAETVA---RARAGAGDGLFQPLLRAVLAHLGQAPFQEFLDSLYFLRFLQWKWLEAQPMGEDWFLDFRVLGRG 196
Fugu GRK1A-1 101 DADRVKKASKILSRYMEPGAKYFCPFLPENGITAIREKHKDAGDDLFTDTLERVLDFLKEVPYTFFLESMYLKRFLQWKWLEMQPMEEDWFLDFRVLGKG 200
Carp GRK1A-1a 101 DKDRAQKAAKILQRYMEPSAKHFCPFLPENDITKVKERHEEAADDLFVQIQASVFDFLKEVPFTFYLETMYFKRFLQWKWLEMQPVAEDWFLDFRVLGKG 200
Carp GRK1A-1b 101 DKDRAQKAAKILQRYMEPSAKLFCPFLPENDITKVKERHEAATDDLFVEILACVFDFLKEVPFTFYLESMYFKRFLQWKWLEMQPVAEDWFLDFRVLGKG 200
Fugu GRK1A-2 587 DSDRAQKASKIVQRYMDPAAKHYCPYLPEDVIAKVKEGQEAVGDDLFAAALATTLDYLREAPFMFFTESMYLKRFLQWKWLETQPIDTDWFLDFRVLGKG 686
Fugu GRK1B 100 EKERGQKAQKLFNKYYESSSKSFCSFLEEKAVARVKEDLKNARSDLFKESEVQVLKHLEKTSVASYKNSMYFLRFVQFKWLESQPIDEEWFMDFRVLGKG 199
Carp GRK1Ba 100 ENDRAKKAQKMVNKYYESSSKNFCNFLGDKAVSRVKEDYKNIRGDLFKESEKQLLVQLEAKALSGFKDSMYFLRYVQFKWLESQPVTEDWFMDFRVLGKG 199
Carp GRK1Bb 0 ---------------------------------------------------------------------------------------------------- 0
GXG
----------------------------------------------------------------------------------------------------
Bovine GRK1 197 GFGEVFACQMKATGKLYACKKLNKKRLKKRKGYQGAMVEKKILAKVHSRFIVSLAYAFETKTDLCLVMTIMNGGDIRYHIYNVDEDNPGFQEPRAIFYTA 296
Fugu GRK1A-1 201 GFGEVSACQMRATGKLYACKKLNKKRLKKRKGYEGAMVEKRILARVHSRFIVSLAYAFQTKTELCLVMTIMNGGDMRYHIYNVDENNPGFQEPRACYYAA 300
Carp GRK1A-1a 201 GFGEVSACQMKATGKLYACKKLNKKRLKKRKGYEGAMVEKRILARVHSRFIVSLAYAFQTKTELCLVMTIMNGGDLRYHIYNVDENNPGFSEARACYYAA 300
Carp GRK1A-1b 201 GFGEVSACQMRATGKLYACKKLNKKRLRKRKGYEGAMVEKRILARVHSRFIVSLAYAFQTKTELCLVMTIMNGGDLRYHIYNVDENNPGFSEARACYYAA 300
Fugu GRK1A-2 687 GFGEVSACQMKATGKLYACKKLNKKRLKKRKGYEGAMVEKRILEKVHSRFIVSLAYAFQTKEELCLIMTIMNGGDLKYHVYLVDENNPGFEEPRACFYIA 786
Fugu GRK1B 200 GFGEVFACQAKATGKMYANKKLDKKRLKKRKGYEGAIVEKRILAKVHSRFIVSLAYAFQTKTDLCLVMTIMNGGDLRFHMYNVDEKNPGFDEKRACFYTA 299
Carp GRK1Ba 200 GFGEVHACQMKATGKMYANKKLNKKRLKKRKGYDGAIIEKRILAKVHSRFIVTLAYAFQTKTDLCLVMTIMNGGDLRYHMYNVDEKNPGFNENRACYYTA 299
Carp GRK1Bb 1 ------------------------------------------------------------------VMTIMNGGDLRFHMYNVDEKNPGFNENRACYYTA 34
XXG
----------------------------------------------------------------------------------------------------
Bovine GRK1 297 QIVSGLEHLHQRNIIYRDLKPENVLLDDDGNVRISDLGLAVELKAGQTKTKGYAGTPGFMAPELLLGEEYDFSVDYFALGVTLYEMIAARGPFRARGEKV 396
Fugu GRK1A-1 301 QIIQGLEHLHQKRIIYRDLKPENVLLDNEGNVRISDLGLAVELADHQDKIKGYAGTPGFMAPELLKGEEYDYSVDYFALGVTVYEFIAAKGPFRTRGEKV 400
Carp GRK1A-1a 301 QIIQGLEHLHQKRIIYRDLKPENVLLDNEGHVRISDLGLAVELADDQLKTKGYAGTPGFMAPELLKGEEYDYSVDYFTLGVTLYEFIAAKGPFRTRGEKV 400
Carp GRK1A-1b 301 QIIQGIEHLHQKRIIYRDLKPENVLLDNEGNVRISDLGLAVELADDQLKTKGYAGTPGFMAPELLKGEEYDYSVDYFTLGVTLYEFIAAKGPFRTRGEKV 400
Fugu GRK1A-2 787 QIIQGLEHLHQKRIIYRDLKPENVLLDNDGNVRISDLGLAVELKEGKTMTKGYAGTPGYMPPEMLKGEKYDSCVDYFSLGVTLFEFLAAKNPFRNRGEKV 886
Fugu GRK1B 300 QIICGLEHLHQHRIVYRDLKPENVLLDDAGHVRLSDLGLAVELPPGKDKTSGYAGTPGFMAPELLEKKEYDYTVDYFTLGVTLYEMIAAKGPFRVRGEKV 399
Carp GRK1Ba 300 QIICGLQHLHQHRIVYRDLKPENVLLDDAGHVRLSDLGLAVELPPGKDKTQGYAGTPGFMAPELLQKKEYDYSVDYFTLGVTLYEMVAAKGPFRCRGEQV 399
Carp GRK1Bb 35 QIICGLEHLHQHRIVYRDLKPENVLLDDAGHVRLSDLGLAVELPPGKDKTQGYAGTPGFMAPELLQKKEYDYTVDYFTLGVTLYEMVAAKGPFRCRGEQV 1134
------------------------------------------------------------------------
Bovine GRK1 397 ENKELKQRVLEQAVTYPDKFSPASKDFCEALLQKDPEKRLGFRDGSCDGLRTHPLFRDISWRQLEAGMLTPPFVPDSRTVYAKNIQDVGAFSTVKGVAFE 496
Fugu GRK1A-1 401 ENKVLKKRVLNDPVTYPEKFSEKARSFCEDLLVREVDKRLGFRNGSCDDLRAHAFFSDINWRKLSAGILTPPFLPDSKTVYAKNIDDVGAFSTVKGVQLE 500
Carp GRK1A-1a 401 ENKEVKKRILNDPVTYPESFSEKAKSVCEGLLAKEVDKRLGFKNGSCDELRTHPFFSEINWRKLDAGILPPPFVPDSKTVYAKNLDDVGAFSTVKGVCLE 500
Carp GRK1A-1b 401 ENKEVKKRILNDPVTYPENFSENAKSICEGLLAKEVDKRLGFKNGTCDELRAHPFFSEINWRKLDAGILPPPFVPDSKTVYAKNLDDVGAFSTVKGVCLE 500
Fugu GRK1A-2 887 EREEMKERMLTRQVEYPDNFSQNAKLLCEGLLAKEMDKRMGFKNGCCDEIRAHPFFTDINWRKLNAGILPPPFVPDPRVVYAKSLDDVGAFSSVKGVNLE 986
Fugu GRK1B 400 ENTEVARRILNDAVSYDPKFTKECKDLCEGLMEKDPAKRLGFSNNTCDVLKSQAFFKEITWGRLEAGMLPPPFVPDPKMVYAKDIDDVGAFSTIKGVVLD 499
Carp GRK1Ba 400 DNNEVTRRILNDPVSYPPTFSQELKDLCEGLMEKDPEKRLVFKNNECSELKNQSFFKELNWGRLEAGMLPPPFVPDPKMVYAKDIDDVGAFSTIKGVVID 499
Carp GRK1Bb 135 DNNEVTRRILNDPVSYPPTFSQELKDLCEGLMEKDPEKRLGFKNNECADLKNQSFFKQLNWGRLEAGMLPPPFVPDPKMVYAKDIDDVGAFSTIKGVVID 234
Bovine GRK1 497 KADTEFFQEFASGTCPIPWQEEMIETGVFGDLNVWRPDGQMPDDMKGVSGQEAAPSSKSGMCVLS 561
Fugu GRK1A-1 501 DADRDFFNEFASGNISIPWQEEMIEMGVYGELTLWGPNGSLPNDLRRESILERP--TKSSTCTVS 563
Carp GRK1A-1a 501 DDDKTFYDEFASGNISIPWQEEMIETGIYGELNVWGPNGTVPNDLRRESILEQP--PKSSTCSIS 563
Carp GRK1A-1b 501 DDDKKFFDEFASGNISIPWQEEMLETGIYGELNVWGPNGTVPNDLRRESILEQP--PKSSTCSVS 563
Fugu GRK1A-2 987 DPDRSFFDEFSSGNISIPWQEEMIDMGIYRELNVWGPEGGVPDDLRRESILEQ---PKSSTCCAS 1048
Fugu GRK1B 500 NKDTEFYADFASGKIPIPWQEEMIETGVFGELNIWGENGKLPNDLDPNYVEAK------------ 552
Carp GRK1Ba 500 NKDSEFYNEFATGNVPIPWQEEMIETGVFGELNVWGQNGKLPNDLDPNYVEAKG-----GGCVLL 559
Carp GRK1Bb 235 NKDNEFYNEFATGNVPIPWQEEMI 258
CaaX
|