Table 2 of
Souied, Mol Vis 2005;
11:1135-1140.Table 2 of
Souied, Mol Vis 2005;
11:1135-1140.
Table 2. Odds ratio for Tyr402His
This table summarizes the odds ratio for heterozygous or homozygous carriers of the Tyr402His carriers in previous studies and in our current study. Our results are adjusted for age and sex ratio. Asterisk indicates odds ratio for individuals harboring one or both alleles with the polymorphism (C carriers: CC and CT).
OR for CT OR for CC
heterozygotes homogygotes
Study AMD Controls (95% CI) (95% CI)
--------------------- --- -------- ------------------ -----------------
Klein [16] 96 50 4.6 (2.0 -11) 7.4 (3.0 -19)
Edwards [17] 400 202 2.7 (1.9 - 3.9)*
Haines [18] 495 185 2.45 (1.41- 4.25) 3.33 (1.79- 6.20)
Total exudative AMD 24 24 3.45 (1.72- 6.92) 5.57 (2.52-12.27)
subgroup
Hageman [19]:
Cohort 1 (Iowa) 403 131 2.82 (2.11- 3.78)*
Cohort 2 (Columbia) 549 272 2.25 (1.79- 2.75)*
Haplotype 1 549 272 2.46 (1.95- 3.11) 3.51 (2.13- 5.78)
(including C)
Zareparsi [20] 616 275 2.44 (2.08- 2.83) 5.93 (4.33- 8.02)
Conley [21] 130 120 3.46 (2.33- 5.13)*
Exudative atrophic 57 120 4.76 (2.87- 7.91)*
This study:
Series F (familial) 81 91 3.54 (1.66- 7.56) 8.08 (3.24-20.14)
Series S (sporadic) 60 91 2.47 (1.12- 5.45) 5.71 (2.23-14.63)
Total 141 91 3.00 (1.60- 5.62) 6.93 (3.11-15.46)
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