Table 1 of
Souied, Mol Vis 2005;
11:1135-1140.
Table 1. Phenotype and genotype frequencies
Exudative AMD groups are compared to controls. There was no statistical difference between the genotype and allele frequencies in Series F and Series S. The p values are for the comparison of patients to controls within each group. Additionally, the genotype frequencies are estimated under the assumption of a Hardy Weinberg Equilibrium (HWE). The χ2 statistics are for the comparison of the HWE genotype frequencies to the observed genotype frequencies. No statistical difference is seen.
Total Series F Series S exudative Parameter (familial) (sporadic) AMD Controls -------------- ---------- ---------- ---------- ---------- Sample size 81 60 141 91 Male (%) 26 (32.1%) 28 (46.7%) 54 (38.3%) 38 (41.8%) Age (±SD) 74.0 ± 9.4 74.9 ± 5.7 74.3 ± 8.0 74.6 ± 6.3 Genotypes frequencies CC 28 (0.346) 20 (0.333) 48 (0.340) 11 (0.121) CT 38 (0.469) 25 (0.417) 63 (0.447) 33 (0.363) TT 15 (0.185) 15 (0.250) 30 (0.213) 47 (0.516) p value <0.0001 <0.0007 <0.0001 Allele frequencies C 47 (0.580) 33 (0.542) 80 (0.564) 27 (0.302) T 34 (0.420) 27 (0.458) 61 (0.436) 64 (0.698) p value <0.0001 <0.0001 <0.0001 Genotype frequencies under HWE CC 17.62 27.25 44.85 8.30 CT 29.79 39.46 69.35 38.37 TT 12.59 14.29 26.80 44.33 χ-sq statistic 1.55 0.11 1.18 1.79 |